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Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis

文献类型：期刊论文

作者Yan, Yong-jie2,3,4; Hu, Hui-xin1,2; Zhang, Yi-jing1,2; Wang, Ling-ling1,2; Pan, Yi-ming1,2; Lui, Simon S. Y.5; Huang, Jia1,2; Chan, Raymond C. K.1,2,3
刊名EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
出版日期2023-07-03
页码13
关键词Negative schizotypal traits Effort-reward imbalance Reward motivation Resting-state functional connectivity
ISSN号0940-1334
DOI10.1007/s00406-023-01640-8
通讯作者Huang, Jia(huangj@psych.ac.cn) ; Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要Reward motivation in individuals with high levels of negative schizotypal traits (NS) has been found to be lower than that in their counterparts. But it is unclear that whether their reward motivation adaptively changes with external effort-reward ratio, and what resting-state functional connectivity (rsFC) is associated with this change. Thirty-five individuals with high levels of NS and 44 individuals with low levels of NS were recruited. A 3T resting-state functional brain scan and a novel reward motivation adaptation behavioural task were administrated in all participants. The behavioural task was manipulated with three conditions (effort > reward condition vs. effort < reward condition vs. effort = reward condition). Under each condition were rated 'wanting' and 'liking' for rewards. The seed-based voxel-wise rsFC analysis was conducted to explore the rsFCs associated with the 'wanting' and 'liking' ratings in individuals with high levels of NS. 'Wanting' and 'liking' ratings of individuals with high levels of NS significantly declined in the effort > reward condition but did not rebound as high as their counterparts in the effort < reward condition. The rsFCs in NS group associated with these ratings were altered. The altered rsFCs in NS group involved regions in the prefrontal lobe, dopaminergic brain regions (ventral tegmental area, substantia nigra), hippocampus, thalamus and cerebellum. Individuals with high levels of NS manifested their reward motivation adaptation impairment as a failure of adjustment adaptively during effort-reward imbalance condition and altered rsFCs in prefrontal, dopaminergic and other brain regions.
收录类别SCI
WOS关键词SCHIZOPHRENIA ; INDIVIDUALS ; CEREBELLUM ; STRESS ; ANHEDONIA ; PLEASURE ; EMOTION ; CORTEX
资助项目CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip K. H. Wong Foundation ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX3415CX]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001021357600001
出版者SPRINGER HEIDELBERG
资助机构CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip K. H. Wong Foundation ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/45630]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Huang, Jia; Chan, Raymond C. K.
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
4.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
5.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Yong-jie,Hu, Hui-xin,Zhang, Yi-jing,et al. Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2023:13.
APA Yan, Yong-jie.,Hu, Hui-xin.,Zhang, Yi-jing.,Wang, Ling-ling.,Pan, Yi-ming.,...&Chan, Raymond C. K..(2023).Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,13.
MLA Yan, Yong-jie,et al."Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023):13.

入库方式： OAI收割

来源：心理研究所

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