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Highly expressed miR-210 in the peripheral blood is closely associated with asphyxiated neonates

文献类型：期刊论文

作者Jin, Ya1,2,3; Xiao, Pei1,4; Lai, Bencong1; Huang, Leiying1; Luo, Qiong1; Chen, Xuming1
刊名TRANSLATIONAL PEDIATRICS
出版日期2023-06-25
页码11
关键词MicroRNA-210 (miR-210) target genes neonatal asphyxia cardiovascular disease neurodevelopment
ISSN号2224-4336
DOI10.21037/tp-23-106
通讯作者Xiao, Pei(graceshaw1128@foxmail.com)
英文摘要Background: In the present study, we aimed to detect microRNA-210 (miR-210) expression in the peripheral blood of neonates with asphyxia and determine the correlation between miR-210 and clinical manifestations and indicators related to pathological changes. Further, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the potential target genes of miR-210 to examine their related diseases and network interactions. Methods: In total, 27 neonates with asphyxia were included in the asphyxia group and 26 healthy neonates were included in the normal group. Quantitative real-time polymerase chain reaction was performed to measure miR-210 expression in the peripheral blood. Furthermore, the correlation between miR-210 expression and asphyxia-related clinical indicators was determined, and the receiver operating characteristic curve analysis of miR-210 was conducted. Moreover, GO and KEGG analyses were conducted to identify the target genes of miR-210. Lastly, the association between miR-210 target genes and autism and epilepsy was elucidated and network interaction analysis was performed to determine the involvement of the target genes of miR-210 in neurological or cardiovascular diseases. Results: miR-210 was highly expressed in the peripheral blood of neonates with asphyxia. Furthermore, the mode of normal delivery, cord potential of hydrogen, and Apgar scores were elevated in these neonates. Additionally, we identified 142 miR-210 target genes, which were associated with both neurodevelopmental and cardiovascular diseases. These genes were associated with the metabolic, cancer, and phosphatidylinositol3-kinase/serine/threonine kinase and mitogen-activated kinase-like protein pathways. Furthermore, 102 miR-210 target genes were associated with autism and epilepsy. Conclusions: High miR-210 expression in the peripheral blood of neonates with asphyxia may be associated with anoxic cerebral injury. The miR-210 target genes are associated with neurodevelopmental and cardiovascular diseases and autism and epilepsy.
收录类别SCI
WOS关键词HYPOXIA ; RNA
资助项目Dongguan Social Science and Technology Development Project[2014108101011]
WOS研究方向Pediatrics
语种英语
WOS记录号WOS:001019024800001
出版者AME PUBLISHING COMPANY
资助机构Dongguan Social Science and Technology Development Project
源URL[http://ir.psych.ac.cn/handle/311026/45638]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Xiao, Pei
作者单位1.Third Peoples Hosp Dongguan, Dept Pediat, Dongguan, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Third Peoples Hosp Dongguan, Dept Pediat, 1 Xianglong Rd, Dongguan 523320, Peoples R China
推荐引用方式
GB/T 7714		 Jin, Ya,Xiao, Pei,Lai, Bencong,et al. Highly expressed miR-210 in the peripheral blood is closely associated with asphyxiated neonates[J]. TRANSLATIONAL PEDIATRICS,2023:11.
APA Jin, Ya,Xiao, Pei,Lai, Bencong,Huang, Leiying,Luo, Qiong,&Chen, Xuming.(2023).Highly expressed miR-210 in the peripheral blood is closely associated with asphyxiated neonates.TRANSLATIONAL PEDIATRICS,11.
MLA Jin, Ya,et al."Highly expressed miR-210 in the peripheral blood is closely associated with asphyxiated neonates".TRANSLATIONAL PEDIATRICS (2023):11.

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来源：心理研究所

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