中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naive patients with schizophrenia: a randomized controlled open-label study

文献类型：期刊论文

作者Lang, Xiaoe1; Xue, Mei2; Zang, Xiaocui2; Wu, Fengchun4,5; Xiu, Meihong3; Zhang, Xiangyang6,7
刊名JOURNAL OF TRANSLATIONAL MEDICINE
出版日期2023-07-04
卷号21期号:1页码:9
关键词Schizophrenia Risperidone First-episode Sertraline Efficacy
DOI10.1186/s12967-023-04272-7
通讯作者Wu, Fengchun(13580380071@163.com) ; Xiu, Meihong(xiumeihong97@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要ObjectiveDespite advances in pharmacology, the treatment of schizophrenia (SZ) remains a challenge due to relapse after antipsychotic discontinuation and multiple adverse effects of antipsychotics. We hypothesized that a low dose of risperidone in combination with sertraline would reduce serious adverse effects without decreasing treatment response. This study aimed to examine the efficacy, safety, and tolerability of low-dose risperidone combined with sertraline to reduce risperidone dose and serious adverse effects in first-episode and medication-naive (FEMN) SZ patients.MethodsA total of 230 patients with FEMN SZ were randomly assigned to receive low-dose risperidone in combination with sertraline (RS group) or regular-dose risperidone (control group). The Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HAMD), and Personal and Social Performance Scale (PSP) were assessed at baseline and the end of the first, second, third, and sixth months. In addition, serum prolactin levels and extrapyramidal symptoms were measured at baseline and follow-up.ResultsRepeated measures ANCOVA showed significant interaction effects of treatment by time on psychotic symptoms, as well as HAMD, PSP scores, prolactin levels, and extrapyramidal symptoms (all p < 0.05). Compared with the control group, the RS group had greater decreases in PANSS total score and its subscores and HAMD score (all p < 0.01) and a greater increase in PSP total score (p < 0.01). Notably, side effects were lower in the RS group relative to the control group. Improvements in HAMD and PANSS total scores, changes in prolactin levels and gender predicted improvements in PSP from baseline to month 6.ConclusionsOur study suggests that low-dose risperidone in combination with sertraline was more effective for psychotic symptoms and psychosocial functioning, with significantly fewer adverse effects in patients with FEMN SZ.Trial registration number: ClinicalTrials.gov, NCT04076371
收录类别SCI
WOS关键词NUCLEUS-ACCUMBENS ; RATING SCALE ; DOUBLE-BLIND ; ANTIPSYCHOTICS ; DOPAMINE ; DEPRESSION ; SYMPTOMS ; DISORDERS ; STRIATUM ; RECOVERY
WOS研究方向Research & Experimental Medicine
语种英语
WOS记录号WOS:001022977500001
出版者BMC
源URL[http://ir.psych.ac.cn/handle/311026/45645]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wu, Fengchun; Xiu, Meihong; Zhang, Xiangyang
作者单位1.Shanxi Med Univ, Dept Psychiat, Hosp 1, Taiyuan, Peoples R China
2.Qingdao Mental Hlth Ctr, Qingdao, Peoples R China
3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China
4.Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou, Peoples R China
5.Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou, Peoples R China
6.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Lang, Xiaoe,Xue, Mei,Zang, Xiaocui,et al. Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naive patients with schizophrenia: a randomized controlled open-label study[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2023,21(1):9.
APA Lang, Xiaoe,Xue, Mei,Zang, Xiaocui,Wu, Fengchun,Xiu, Meihong,&Zhang, Xiangyang.(2023).Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naive patients with schizophrenia: a randomized controlled open-label study.JOURNAL OF TRANSLATIONAL MEDICINE,21(1),9.
MLA Lang, Xiaoe,et al."Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naive patients with schizophrenia: a randomized controlled open-label study".JOURNAL OF TRANSLATIONAL MEDICINE 21.1(2023):9.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。