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Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information

文献类型：期刊论文

作者Wang, Yue1,2; Liu, Naizheng1,2; Ma, Longyu1,2; Yue, Lupeng5,6; Cui, Shuang1,2; Liu, Feng-Yu1,2; Yi, Ming1,2,3; Wan, You1,2,3,4
刊名NEUROSCIENCE BULLETIN
出版日期2023-07-13
页码17
关键词Ventral hippocampal CA1 Nociception Mechanical allodynia In vivo recording Neural coding
ISSN号1673-7067
DOI10.1007/s12264-023-01086-x
通讯作者Wan, You(ywan@hsc.pku.edu.cn)
英文摘要As a main structure of the limbic system, the hippocampus plays a critical role in pain perception and chronicity. The ventral hippocampal CA1 (vCA1) is closely associated with negative emotions such as anxiety, stress, and fear, yet how vCA1 neurons encode nociceptive information remains unclear. Using in vivo electrophysiological recording, we characterized vCA1 pyramidal neuron subpopulations that exhibited inhibitory or excitatory responses to plantar stimuli and were implicated in encoding stimuli modalities in naive rats. Functional heterogeneity of the vCA1 pyramidal neurons was further identified in neuropathic pain conditions: the proportion and magnitude of the inhibitory response neurons paralleled mechanical allodynia and contributed to the confounded encoding of innocuous and noxious stimuli, whereas the excitatory response neurons were still instrumental in the discrimination of stimulus properties. Increased theta power and theta-spike coupling in vCA1 correlated with nociceptive behaviors. Optogenetic inhibition of vCA1 pyramidal neurons induced mechanical allodynia in naive rats, whereas chemogenetic reversal of the overall suppressed vCA1 activity had analgesic effects in rats with neuropathic pain. These results provide direct evidence for the representations of nociceptive information in vCA1.
收录类别SCI
WOS关键词MEDIAL PREFRONTAL CORTEX ; NEUROPATHIC PAIN ; FIELD CA1 ; THETA OSCILLATIONS ; WORKING-MEMORY ; CONNECTIVITY ; PERSISTENT ; DORSAL ; DIVERSITY ; RESPONSES
资助项目National Natural Science Foundation of China[81974166] ; National Natural Science Foundation of China[32271053] ; National Natural Science Foundation of China[31872774]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001024556500001
出版者SPRINGER
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/45658]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wan, You
作者单位1.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100083, Peoples R China
3.Peking Univ, Key Lab Neurosci, Minist Educ, Natl Hlth Commiss, Beijing 100083, Peoples R China
4.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yue,Liu, Naizheng,Ma, Longyu,et al. Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information[J]. NEUROSCIENCE BULLETIN,2023:17.
APA Wang, Yue.,Liu, Naizheng.,Ma, Longyu.,Yue, Lupeng.,Cui, Shuang.,...&Wan, You.(2023).Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information.NEUROSCIENCE BULLETIN,17.
MLA Wang, Yue,et al."Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information".NEUROSCIENCE BULLETIN (2023):17.

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来源：心理研究所

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