Ionizing radiation alters functional neurotransmission in Drosophila larvae
文献类型：期刊论文
| 作者 | Zhang, Yi1; Zhang, Yihao2,3; Shen, Cong4; Hao, Shun2,3; Duan, Wenlan2,3; Liu, Li2,3,5 ; Wei, Hongying2,3
|
| 刊名 | FRONTIERS IN CELLULAR NEUROSCIENCE
 |
| 出版日期 | 2023-07-06 |
| 卷号 | 17页码:14 |
| 关键词 | ionizing radiation neurotransmission dopamine tyramine PTTH neurons Drosophila larvae |
| DOI | 10.3389/fncel.2023.1151489 |
| 通讯作者 | Wei, Hongying(weihongying@ibp.ac.cn) |
| 英文摘要 | IntroductionPatients undergoing cranial ionizing radiation therapy for brain malignancies are at increased risk of long-term neurocognitive decline, which is poorly understood and currently untreatable. Although the molecular pathogenesis has been intensively researched in many organisms, whether and how ionizing radiation alters functional neurotransmission remains unknown. This is the first study addressing physiological changes in neurotransmission after ionizing radiation exposure. MethodsTo elucidate the cellular mechanisms of radiation damage, using calcium imaging, we analyzed the effects of ionizing radiation on the neurotransmitter-evoked responses of prothoracicotropic hormone (PTTH)-releasing neurons in Drosophila larvae, which play essential roles in normal larval development. ResultsThe neurotransmitters dopamine and tyramine decreased intracellular calcium levels of PTTH neurons in a dose-dependent manner. In gamma irradiated third-instar larvae, a dose of 25 Gy increased the sensitivity of PTTH neurons to dopamine and tyramine, and delayed development, possibly in response to abnormal functional neurotransmission. This irradiation level did not affect the viability and arborization of PTTH neurons and successful survival to adulthood. Exposure to a 40-Gy dose of gamma irradiation decreased the neurotransmitter sensitivity, physiological viability and axo-dendritic length of PTTH neurons. These serious damages led to substantial developmental delays and a precipitous reduction in the percentage of larvae that survived to adulthood. Our results demonstrate that gamma irradiation alters neurotransmitter-evoked responses, indicating synapses are vulnerable targets of ionizing radiation. DiscussionThe current study provides new insights into ionizing radiation-induced disruption of physiological neurotransmitter signaling, which should be considered in preventive therapeutic interventions to reduce risks of neurological deficits after photon therapy. |
| 收录类别 | SCI |
| WOS关键词 | LONG-TERM POTENTIATION ; SYNAPTIC PLASTICITY ; OXIDATIVE STRESS ; GENOME INTEGRITY ; ADULT SURVIVORS ; IRRADIATION ; CELLS ; MODEL ; LIPOPOLYSACCHARIDE ; BIOSYNTHESIS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:001029427900001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45671]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Wei, Hongying |
| 作者单位 | 1.North China Res Inst Electroopt, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromolecules, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 4.China Elect Technol Grp Corp, Res Inst 45, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yi,Zhang, Yihao,Shen, Cong,et al. Ionizing radiation alters functional neurotransmission in Drosophila larvae[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2023,17:14. |
| APA | Zhang, Yi.,Zhang, Yihao.,Shen, Cong.,Hao, Shun.,Duan, Wenlan.,...&Wei, Hongying.(2023).Ionizing radiation alters functional neurotransmission in Drosophila larvae.FRONTIERS IN CELLULAR NEUROSCIENCE,17,14. |
| MLA | Zhang, Yi,et al."Ionizing radiation alters functional neurotransmission in Drosophila larvae".FRONTIERS IN CELLULAR NEUROSCIENCE 17(2023):14. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。