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Sex difference in association between tardive dyskinesia and cognitive deficits in patients with chronic schizophrenia

文献类型：期刊论文

作者Zhang, Wanni1,2; Wang, Dongmei3,4; Zhou, Huixia3,4; Chen, Dachun5; Xiu, Meihong5; Cui, Lixia1,2,6,7; Zhang, Xiangyang3,4,8
刊名SCHIZOPHRENIA RESEARCH
出版日期2023-05-01
卷号255页码:140-147
ISSN号0920-9964
关键词Schizophrenia Tardive dyskinesia Cognition Sex differences
DOI10.1016/j.schres.2023.03.034
通讯作者Cui, Lixia(clx668@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: Tardive dyskinesia (TD), a side effect due to long-term use of antipsychotic medication, is associated with cognitive impairment. Several studies have found sex differences in cognitive impairment in schizophrenia patients, while whether there are sex differences in cognitive performance in schizophrenia patients with TD has not been reported.Methods: A total of 496 schizophrenia inpatients and 362 healthy controls were recruited for this study. We used the Positive and Negative Syndrome Scale (PANSS) to assess patients' psychopathological symptoms and the Abnormal Involuntary Movement Scale (AIMS) to assess the severity of TD. Cognitive function was measured in 313 of these inpatients and 310 of healthy controls using the Repeatable Battery for Assessment of Neuropsy-chological Status (RBANS).Results: Patients with schizophrenia performed worse in all cognitive domains than healthy controls(all p < 0.001). Compared to patients without TD, patients with TD had higher PANSS total, PANSS negative symptom subscale and AIMS scores (all p < 0.001), while RBANS total, visuospatial/constructional and attention subscale scores were significantly lower (all p < 0.05). In addition, the visuospatial/constructional and attention indices remained significantly lower in male patients with TD than those without TD (both p < 0.05), but these results were not observed in female patients. Moreover, visuospatial/constructional and attention indices were nega-tively correlated with total AIMS scores only in male patients (both p < 0.05).Conclusion: Our results suggest that there may be sex differences in cognitive impairment in schizophrenia pa-tients with comorbid TD, indicating that female gender may have a protective effect on cognitive impairment in schizophrenia patients caused by TD.
收录类别SCI
WOS关键词OXIDATIVE STRESS ; GENDER-DIFFERENCES ; NEUROPSYCHOLOGICAL PERFORMANCE ; SUPEROXIDE-DISMUTASE ; IMPAIRMENT ; PREVALENCE ; SYMPTOMS ; RISK ; DYSFUNCTION ; ESTROGEN
资助项目Beijing Philosophy and Social Science Planning Program and Social Science Research Key Program of Beijing Municipal Commission of Education[SZ202210028012] ; CAS International Cooperation Research Program[153111KYSB20190004]
WOS研究方向Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:001026290300001
资助机构Beijing Philosophy and Social Science Planning Program and Social Science Research Key Program of Beijing Municipal Commission of Education ; CAS International Cooperation Research Program
源URL[http://ir.psych.ac.cn/handle/311026/45727]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Cui, Lixia; Zhang, Xiangyang
作者单位1.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning & Cognit, Beijing, Peoples R China
2.Capital Normal Univ, Sch Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA
6.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning & Cognit, Beijing 100037, Peoples R China
7.Capital Normal Univ, Sch Psychol, Beijing 100037, Peoples R China
8.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Wanni,Wang, Dongmei,Zhou, Huixia,et al. Sex difference in association between tardive dyskinesia and cognitive deficits in patients with chronic schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2023,255:140-147.
APA Zhang, Wanni.,Wang, Dongmei.,Zhou, Huixia.,Chen, Dachun.,Xiu, Meihong.,...&Zhang, Xiangyang.(2023).Sex difference in association between tardive dyskinesia and cognitive deficits in patients with chronic schizophrenia.SCHIZOPHRENIA RESEARCH,255,140-147.
MLA Zhang, Wanni,et al."Sex difference in association between tardive dyskinesia and cognitive deficits in patients with chronic schizophrenia".SCHIZOPHRENIA RESEARCH 255(2023):140-147.

入库方式： OAI收割

来源：心理研究所

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