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Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration

文献类型：期刊论文

作者Xing, Yan1,2; Liang, Shan3; Zhang, Limei2; Ni, He1; Zhang, Xueqin2; Wang, Jiancheng2; Yang, Liu1; Song, Shuangshuang2; Li, Hai-Hang1; Jia, Chenxi4
刊名SCIENTIFIC REPORTS
出版日期2023-05-24
卷号13期号:1页码:12
ISSN号2045-2322
DOI10.1038/s41598-023-34219-3
通讯作者Li, Hai-Hang(li8341@163.com) ; Jia, Chenxi(cjia@ncpsb.org.cn) ; Jin, Feng(jinfeng@psych.ac.cn)
英文摘要It is important to explore the effective approaches to prevent dry age-related macular degeneration (AMD). In this study, significantly decreased full-field electroretinograms wave amplitudes and disordered retina structures were detected in rat retinas of sodium iodate induced dry AMD model. Six a- and b-wave amplitudes and the antioxidant activities were significantly increased, and the outer nuclear layer thickness was significantly improved in the rat retinas treated with the combination of Lactobacillus fermentum NS9 (LF) and aronia anthocyanidin extract (AAE) compared with the model. The effects were much better than the treatment with AAE alone. The proteomics analysis showed the expressions of alpha-, beta- and gamma-crystallins were increased by 3-8 folds in AAE treated alone and by 6-11 folds in AAE + LF treatment compared with the model, which was further confirmed by immuno-blotting analysis. Analysis of gut microbial composition indicated that higher abundance of the genus Parasutterella and species P. excrementihominis was found in the AAE + LF treatment compared with the other groups. The results indicated that the combined treatment of AAE + LF is a potential way to prevent the retina degeneration which is significantly better than the AAE treated alone.
收录类别SCI
WOS关键词CRYSTALLINS
资助项目Eye Hospital, China Academy of Chinese Medical Sciences ; National Key R&D Program of China[2021YFA1302601]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PORTFOLIO
WOS记录号WOS:000995835600032
资助机构Eye Hospital, China Academy of Chinese Medical Sciences ; National Key R&D Program of China
源URL[http://ir.psych.ac.cn/handle/311026/45733]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Hai-Hang; Jia, Chenxi; Jin, Feng
作者单位1.South China Normal Univ, Sch Life Sci, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Peoples R China
2.Guozhen Hlth Technol Beijing Co Ltd, Res Lab Antioxidat & Antiaging, Beijing 102206, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China
4.Beijing Proteome Res Ctr, Natl Ctr Prot Sci, PHOENIX Ctr, Inst Life,State Key Lab Proteom, Beijing 102206, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Xing, Yan,Liang, Shan,Zhang, Limei,et al. Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration[J]. SCIENTIFIC REPORTS,2023,13(1):12.
APA Xing, Yan.,Liang, Shan.,Zhang, Limei.,Ni, He.,Zhang, Xueqin.,...&Jin, Feng.(2023).Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration.SCIENTIFIC REPORTS,13(1),12.
MLA Xing, Yan,et al."Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration".SCIENTIFIC REPORTS 13.1(2023):12.

入库方式： OAI收割

来源：心理研究所

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