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Thyroid dysfunction in young, first-episode and drug-naive patients with major depressive disorder: prevalence and associated clinical factors

文献类型：期刊论文

作者Wu, Jinbo1; Wang, Zhunian2; Xu, Hongjiao2; Yang, Liying3; Liu, Jiacheng1; Zheng, Yue4; Kang, Chuanyi1; Wang, Xiaohong1; Shi, Jingjing1; Zhao, Na1
刊名FRONTIERS IN PSYCHIATRY
出版日期2023-06-30
卷号14页码:7
关键词major depressive disorder prevalence association metabolize thyroid dysfunction
ISSN号1664-0640
DOI10.3389/fpsyt.2023.1156481
通讯作者Zhao, Na(zhaona@hrbmu.edu.cn) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要Objective: The incidence of thyroid dysfunction (TD) and major depressive disorder (MDD) is increasing year by year in the general population. However, the prevalence and correlates of TD in first-episode drug-naive (FEDN) MDD patients have not been explored. This study sought to fill this gap and examine the association between TD and MDD. Methods: We recruited 1,289 FEDN MDD patients aged 18 similar to 45years. A total of 1,289 FEDN MDD outpatients were recruited. Demographical and suicide data were collected for each patient, and lipid profiles, thyroid function, and fasting blood glucose (FBG) levels were measured. The Hamilton Depression Scale 17 (HAMD-17) was assessed for depression. Results: The prevalence of TD in young FEDN MDD patients was 64.86%. Compared with those without TD, patients with TD had longer duration of illness, greater HAMD score, higher BMI, TG, TC, and LDL-C levels, and higher suicide attempt rates, but lower HDL-C and FBG levels. Further logistic regression indicated that duration of illness, HAMD score, TC, HDL-C, BMI, and FBG levels were significantly associated with TD. Limitations: No causal relationship can be drawn due to the cross-sectional design. Conclusion: TD is common in young FEDN MDD patients. So clinicians should monitor thyroid function in patients with MDD.
收录类别SCI
WOS关键词HORMONE ; AUTOIMMUNITY ; DISEASE
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001025075400001
出版者FRONTIERS MEDIA SA
源URL[http://ir.psych.ac.cn/handle/311026/45754]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhao, Na; Zhang, Xiang Yang
作者单位1.Harbin Med Univ, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
2.Qingdao Mental Hlth Ctr, Qingdao, Peoples R China
3.Dalian 7 Peoples Hosp, Dalian, Liaoning, Peoples R China
4.Peking Univ Sixth Hosp, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Jinbo,Wang, Zhunian,Xu, Hongjiao,et al. Thyroid dysfunction in young, first-episode and drug-naive patients with major depressive disorder: prevalence and associated clinical factors[J]. FRONTIERS IN PSYCHIATRY,2023,14:7.
APA Wu, Jinbo.,Wang, Zhunian.,Xu, Hongjiao.,Yang, Liying.,Liu, Jiacheng.,...&Zhang, Xiang Yang.(2023).Thyroid dysfunction in young, first-episode and drug-naive patients with major depressive disorder: prevalence and associated clinical factors.FRONTIERS IN PSYCHIATRY,14,7.
MLA Wu, Jinbo,et al."Thyroid dysfunction in young, first-episode and drug-naive patients with major depressive disorder: prevalence and associated clinical factors".FRONTIERS IN PSYCHIATRY 14(2023):7.

入库方式： OAI收割

来源：心理研究所

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