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Association between triglyceride glucose index and suicide attempts in patients with first-episode drug-naive major depressive disorder

文献类型：期刊论文

作者Liu, Junjun1,2,3; Zhu, Xiaomin2; Liu, Yang1; Jia, Fengnan2,3; Yuan, Hsinsung1; Wang, Qingyuan4; Zhang, Xiaobin2; Li, Zhe2; Du, Xiangdong2,3; Zhang, Xiangyang5
刊名FRONTIERS IN PSYCHIATRY
出版日期2023-07-28
卷号14页码:9
ISSN号1664-0640
关键词triglyceride glucose index suicide attempts insulin resistance major depressive disorder association
DOI10.3389/fpsyt.2023.1231524
通讯作者Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要ObjectiveTriglyceride glucose (TyG) index has been suggested as an alternative indicator of insulin resistance (IR); however, the association between TyG index and suicide attempts (SA) in major depressive disorder (MDD) is unclear. The aim of this study was to investigate the relationship between TyG index and SA in Chinese patients with first-episode drug-naive (FEDN) MDD. MethodsThis cross-sectional study enrolled 1,718 patients with FEDN MDD aged 34.9 & PLUSMN; 12.4 years from the First Hospital of Shanxi Medical University (Taiyuan, Shanxi Province, China) from September 2016 to December 2018. Multivariable binary logistic regression analysis was used to estimate the association between TyG index and the risk of SA. A two-piecewise linear regression model was used to investigate the threshold effects if non-linearity associations existed. Interaction and stratified analyses were performed based on sex, education, marital status, comorbid anxiety, and psychotic symptoms. ResultsMultivariable logistic regression analysis revealed that TyG index was positively associated with the risk of SA after adjusting for confounders (OR = 1.35, 95% CI: 1.04-1.75, p = 0.03). Smoothing plots also showed a nonlinear relationship between TyG index and SA, with the inflection point of TyG index being 9.29. On the right of the inflection point, a positive association between TyG index and SA was detected (OR = 3.47, 95% CI: 1.81 to 6.66, p < 0.001), while no significant association was observed on the left side of the inflection point (OR = 1.14, 95% CI: 0.79 to 1.66, p = 0.476). ConclusionThe relationship between TyG index and SA risk was non-linear and exhibited a threshold effect in Chinese patients with FEDN MDD. When TyG index was greater than 9.29, they showed a significant positive correlation.
收录类别SCI
WOS关键词BODY-MASS INDEX ; CARDIOVASCULAR-DISEASE ; INSULIN-RESISTANCE ; DIABETES-MELLITUS ; INFLAMMATION ; METAANALYSIS ; INDIVIDUALS ; MULTICENTER ; ACTIVATION ; CYTOKINES
资助项目Gusu Talent Program[GSWS2021052] ; Gusu Talent Program[GSWS2021053] ; Gusu Talent Program[GSWS2019070] ; Key Diagnosis and Treatment Program of Suzhou[LCZX202016] ; Suzhou Clinical Medical Center for Mood Disorders[Szlcyxzx202109] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK21216] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK20184] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK22264]
WOS研究方向Psychiatry
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:001045984200001
资助机构Gusu Talent Program ; Key Diagnosis and Treatment Program of Suzhou ; Suzhou Clinical Medical Center for Mood Disorders ; Medical Science and Technology Development Foundation, Nanjing Department of Health
源URL[http://ir.psych.ac.cn/handle/311026/45834]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Du, Xiangdong; Zhang, Xiangyang
作者单位1.Nanjing Meishan Hosp, Nanjing, Peoples R China
2.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China
3.Soochow Univ, Med Coll, Suzhou, Peoples R China
4.Nanjing Med Univ, Clin Med Coll 2, Clin Med Dept, Nanjing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Junjun,Zhu, Xiaomin,Liu, Yang,et al. Association between triglyceride glucose index and suicide attempts in patients with first-episode drug-naive major depressive disorder[J]. FRONTIERS IN PSYCHIATRY,2023,14:9.
APA Liu, Junjun.,Zhu, Xiaomin.,Liu, Yang.,Jia, Fengnan.,Yuan, Hsinsung.,...&Zhang, Xiangyang.(2023).Association between triglyceride glucose index and suicide attempts in patients with first-episode drug-naive major depressive disorder.FRONTIERS IN PSYCHIATRY,14,9.
MLA Liu, Junjun,et al."Association between triglyceride glucose index and suicide attempts in patients with first-episode drug-naive major depressive disorder".FRONTIERS IN PSYCHIATRY 14(2023):9.

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来源：心理研究所

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