Prevalence and clinical correlates of psychotic symptoms in first-episode untreated female chinese patients with major depressive disorder
文献类型：期刊论文
| 作者 | Peng, Ruijie1,2; Zhang, Xiaobin2; Li, Ronghua2; Zhang, Guangya2; Yue, Yan1,2; Wu, Siqi2,3; Wu, Yuxuan1,2; Yang, Ruchang1,2; Zhou, Yue2,4; Du, Xiangdong2 |
| 刊名 | BMC PSYCHIATRY
 |
| 出版日期 | 2023-07-28 |
| 卷号 | 23期号:1页码:8 |
| 关键词 | Depression Females First episode Psychotic depression Suicide attempt Thyroid dysfunction |
| DOI | 10.1186/s12888-023-05011-4 |
| 通讯作者 | Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | BackgroundRecent studies have reported that psychotic symptoms are common in patients with major depressive disorder (MDD). However, few studies have reported the relationship between thyroid function, lipid metabolism and clinical profiles in female MDD patients. Thus, this study aimed to investigate the prevalence of psychotic depression (PD) and its risk factors in first-episode and drug naive (FEDN) depression among the female population in China.MethodsThis was a cross-sectional study involving a representative probability sample of 1,130 FEDN female outpatients with MDD (aged 18 years or older) in China. We collected information relating to socio-demographic characteristics, clinical data and blood samples. The Hamilton Depression Rating Scale 17-item version (HAMD-17), Hamilton Anxiety Rating Scale 14-item version (HAMA-14), and Positive and Negative Syndrome Scale (PANSS) were used to evaluate depressive, anxiety, and psychotic symptoms.ResultsThe prevalence of psychotic symptoms in female MDD patients was 10.97%. The findings revealed significant differences between MDD female patients with psychotic symptoms and non-PD female patients in the following areas: higher HAMD scores, higher HAMA scores, more severe anxiety and an increased risk of suicide attempts. Further logistic regression analysis showed that psychotic symptoms were associated with higher thyroid-stimulating hormone (TSH) levels and an odds ratio of 1.168.ConclusionsOur findings supported the hypothesis that higher TSH levels were correlated with psychotic symptoms in female MDD patients. Therefore, serum TSH levels may be a potential biomarker of PD in female MDD patients. In addition, we found that PD was closely associated with suicide attempts and lipid levels, but did not reach statistical significance. |
| 收录类别 | SCI |
| WOS关键词 | THYROID-STIMULATING-HORMONE ; SUICIDE ATTEMPTS ; SERUM-CHOLESTEROL ; RISK-FACTORS ; ASSOCIATION ; GENDER ; PATTERNS ; FEATURES ; ANXIETY ; HEALTH |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| 出版者 | BMC |
| WOS记录号 | WOS:001039530100001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45852]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Du, Xiangdong; Zhang, Xiangyang |
| 作者单位 | 1.Soochow Univ, Med Coll, Suzhou, Peoples R China 2.Soochow Univ, Guangji Hosp, Inst Suzhou Psychiat Hosp, Suzhou 215131, Peoples R China 3.North China Univ Sci & Technol, Sch Psychol & Mental Hlth, Qinhuangdao, Peoples R China 4.Xuzhou Med Univ, Xuzhou, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Ruijie,Zhang, Xiaobin,Li, Ronghua,et al. Prevalence and clinical correlates of psychotic symptoms in first-episode untreated female chinese patients with major depressive disorder[J]. BMC PSYCHIATRY,2023,23(1):8. |
| APA | Peng, Ruijie.,Zhang, Xiaobin.,Li, Ronghua.,Zhang, Guangya.,Yue, Yan.,...&Zhang, Xiangyang.(2023).Prevalence and clinical correlates of psychotic symptoms in first-episode untreated female chinese patients with major depressive disorder.BMC PSYCHIATRY,23(1),8. |
| MLA | Peng, Ruijie,et al."Prevalence and clinical correlates of psychotic symptoms in first-episode untreated female chinese patients with major depressive disorder".BMC PSYCHIATRY 23.1(2023):8. |
入库方式： OAI收割
来源：心理研究所
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