Differences in the prevalence and clinical correlates of comorbid suicide attempts in patients with early- and late-onset major depressive disorder
文献类型：期刊论文
| 作者 | Huang, Xiao1; Sun, Yuan2; Wu, Anshi1; Zhang, Xiangyang3,4
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| 刊名 | FRONTIERS IN PSYCHIATRY
 |
| 出版日期 | 2023-08-01 |
| 卷号 | 14页码:8 |
| 关键词 | MDD (major depressive disorder) suicide attempts age at onset prevalence outpatients |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2023.1173917 |
| 通讯作者 | Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | ObjectiveThere are many studies on differences in the onset age of major depressive disorder (MDD) patients. However, study on differences in clinical correlates of suicide attempts between early- and late-onset MDD patients is limited. The aim of this study was to investigate the differences in the prevalence and clinical correlates of suicide attempts in patients with early- and late-onset MDD in China. MethodsA total of 1718 adult outpatients with MDD were recruited. Demographic and clinical data were collected. The 17-item Hamilton Rating Scale for Depression (HAMD-17), Hamilton Anxiety Rating Scale (HAMA), Positive and Negative Syndrome Scale (PANSS) positive subscale, and Clinical Global Impression-Severity (CGI-S) Scales were used to assess their depressive, anxiety, psychotic symptoms, and the severity of the clinical symptoms, respectively. ResultsThe prevalence of suicide attempts was higher in late-onset MDD patients (291/1369, 21.3%) than in early-onset MDD patients (55/349, 15.8%) (p = 0.023). However after Bonferroni correction no significant difference was found in the prevalence of suicide attempts in late-onset and late-onset MDD patients (p > 0.05). In both early- and late-onset groups, univariate analysis showed that the following characteristics were significantly associated with suicide attempts: HAMA, HAMD and PANSS positive subscale scores, thyroid stimulating hormone (TSH) levels, blood glucose levels, systolic blood pressure (SBP), and diastolic blood pressure (DBP). In both the early- and late-onset groups, the prevalence rates of severe anxiety disorder and psychotic symptoms were significantly higher in the suicide attempt group than in the non-suicide attempt group. In regression analysis, disease duration, TSH levels and HAMA score were independently associated with suicide attempts in the early-onset group, while TSH levels, HAMA and HAMD score were independently associated with suicide attempts in the late-onset group. ConclusionThis study suggests that suicide attempts are not frequent in early-onset outpatients with MDD compared with late-onset, and some clinical correlates are associated with suicide attempt in early- and late-onset MDD. |
| 收录类别 | SCI |
| WOS关键词 | AGE ; IDEATION ; FEATURES ; DISEASE ; CHINA |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001047636000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45870]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiangyang |
| 作者单位 | 1.Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, Beijing, Peoples R China 2.Capital Med Univ, Beijing Chao Yang Hosp, Dept Pharm, Beijing, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xiao,Sun, Yuan,Wu, Anshi,et al. Differences in the prevalence and clinical correlates of comorbid suicide attempts in patients with early- and late-onset major depressive disorder[J]. FRONTIERS IN PSYCHIATRY,2023,14:8. |
| APA | Huang, Xiao,Sun, Yuan,Wu, Anshi,&Zhang, Xiangyang.(2023).Differences in the prevalence and clinical correlates of comorbid suicide attempts in patients with early- and late-onset major depressive disorder.FRONTIERS IN PSYCHIATRY,14,8. |
| MLA | Huang, Xiao,et al."Differences in the prevalence and clinical correlates of comorbid suicide attempts in patients with early- and late-onset major depressive disorder".FRONTIERS IN PSYCHIATRY 14(2023):8. |
入库方式： OAI收割
来源：心理研究所
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