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Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

文献类型：期刊论文

作者Liu, Nana1,2; Zhang, Longjiang3; Tian, Tian4; Cheng, Jingliang5; Zhang, Bing6; Qiu, Shijun7; Geng, Zuojun8; Cui, Guangbin9,10; Zhang, Quan11; Liao, Weihua12,13,14
刊名NATURE GENETICS
出版日期2023-06-19
页码20
ISSN号1061-4036
DOI10.1038/s41588-023-01425-8
通讯作者Wang, Meiyun(mywang@ha.edu.cn) ; Ye, Zhaoxiang(yezhaoxiang@163.com) ; Yu, Chunshui(chunshuiyu@tmu.edu.cn)
英文摘要The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function. Genome-wide association studies on hippocampal and subfield volumes are mainly conducted in European populations; however, other ancestral populations are under-represented. Here we conduct cross-ancestry genome-wide association meta-analyses in 65,791 individuals for hippocampal volume and 38,977 for subfield volumes, including 7,009 individuals of East Asian ancestry. We identify 339 variant-trait associations at P < 1.13 x 10(-9) for 44 hippocampal traits, including 23 new associations. Common genetic variants have similar effects on hippocampal traits across ancestries, although ancestry-specific associations exist. Cross-ancestry analysis improves the fine-mapping precision and the prediction performance of polygenic scores in under-represented populations. These genetic variants are enriched for Wnt signaling and neuron differentiation and affect cognition, emotion and neuropsychiatric disorders. These findings may provide insight into the genetic architectures of hippocampal and subfield volumes. Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant-trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.
收录类别SCI
WOS关键词COMMON VARIANTS ; BRAIN ; GENE ; DISEASE ; SEGMENTATION ; NEUROGENESIS ; PROGRESSION ; DISRUPTION ; ENRICHMENT ; PLASTICITY
资助项目National Natural Science Foundation of China[82030053] ; National Natural Science Foundation of China[81425013]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:001012076800003
出版者NATURE PORTFOLIO
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/45769]  
专题心理研究所_认知与发展心理学研究室
通讯作者Wang, Meiyun; Ye, Zhaoxiang; Yu, Chunshui
作者单位1.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China
3.Nanjing Univ, Jinling Hosp, Affiliated Hosp, Med Sch,Dept Radiol, Nanjing, Peoples R China
4.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan, Peoples R China
5.Zhengzhou Univ, Dept Magnet Resonance Imaging, Affiliated Hosp 1, Zhengzhou, Peoples R China
6.Nanjing Univ, Drum Tower Hosp, Med Sch, Dept Radiol, Nanjing, Peoples R China
7.Guangzhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Med Imaging, Guangzhou, Peoples R China
8.Hebei Med Univ, Hosp 2, Dept Med Imaging, Shijiazhuang, Peoples R China
9.Air Force Med Univ, Funct & Mol Imaging Key Lab Shaanxi Prov, Xian, Peoples R China
10.Air Force Med Univ, Tangdu Hosp, Dept Radiol, Xian, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Nana,Zhang, Longjiang,Tian, Tian,et al. Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes[J]. NATURE GENETICS,2023:20.
APA Liu, Nana.,Zhang, Longjiang.,Tian, Tian.,Cheng, Jingliang.,Zhang, Bing.,...&CHIMGEN Consortium.(2023).Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.NATURE GENETICS,20.
MLA Liu, Nana,et al."Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes".NATURE GENETICS (2023):20.

入库方式： OAI收割

来源：心理研究所

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