Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia
文献类型：期刊论文
| 作者 | Huang, Huan1; Rong, Bei1; Chen, Cheng1; Wan, Qirong1; Liu, Zhongchun1; Zhou, Yuan2 ; Wang, Gaohua1,3; Wang, Huiling1,4,5
|
| 刊名 | BRAIN SCIENCES
 |
| 出版日期 | 2023-07-01 |
| 卷号 | 13期号:7页码:13 |
| 关键词 | schizophrenia depression resting-state functional magnetic resonance imaging intrinsic connectivity contrast functional connectivity |
| DOI | 10.3390/brainsci13070997 |
| 通讯作者 | Wang, Huiling(hlwang@whu.edu.cn) |
| 英文摘要 | Schizophrenia and depression are psychiatric disorders with overlapping clinical and biological features. This study aimed to identify common and distinct neuropathological mechanisms in schizophrenia and depression patients using resting-state functional magnetic resonance imaging (fMRI). The study included 28 patients with depression (DEP), 29 patients with schizophrenia (SCH), and 30 healthy control subjects (HC). Intrinsic connectivity contrast (ICC) was used to identify functional connectivity (FC) changes at the whole-brain level, and significant ICC differences were found in the bilateral orbitofrontal cortex (OFC) across all three groups. Further seed-based FC analysis indicated that compared to the DEP and HC groups, the FC between bilateral OFC and medial prefrontal cortex (MPFC), right anterior insula, and right middle frontal gyrus were significantly lower in the SCH group. Additionally, the FC between right OFC and left thalamus was decreased in both patient groups compared to the HC group. Correlation analysis showed that the FC between OFC and MPFC was positively correlated with cognitive function in the SCH group. These findings suggest that OFC connectivity plays a critical role in the pathophysiology of schizophrenia and depression and may provide new insights into the potential neural mechanisms underlying these two disorders. |
| 收录类别 | SCI |
| WOS关键词 | DEFAULT MODE ; PREFRONTAL CORTEX ; NETWORK ; IMPAIRMENT ; DISORDERS ; SCALE |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:001035072800001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45778]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 通讯作者 | Wang, Huiling |
| 作者单位 | 1.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430060, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 3.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Peoples R China 4.Wuhan Univ, Dept Psychiat, Zhongxiang Hosp, Renmin Hosp, Zhongxiang 431900, Peoples R China 5.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Huan,Rong, Bei,Chen, Cheng,et al. Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia[J]. BRAIN SCIENCES,2023,13(7):13. |
| APA | Huang, Huan.,Rong, Bei.,Chen, Cheng.,Wan, Qirong.,Liu, Zhongchun.,...&Wang, Huiling.(2023).Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia.BRAIN SCIENCES,13(7),13. |
| MLA | Huang, Huan,et al."Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in Depression and Schizophrenia".BRAIN SCIENCES 13.7(2023):13. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。