Gender differences in the association between anxiety symptoms and thyroid hormones in young patients with first-episode and drug na & iuml;ve major depressive disorder
文献类型:期刊论文
作者 | Zhao, Ying1; Liu, Jia Cheng2; Yu, Feng3; Yang, Li Ying2; Kang, Chuan Yi2; Yan, Li Juan1; Liu, Si Tong4; Zhao, Na2; Wang, Xiao Hong2; Zhang, Xiang Yang5,6 |
刊名 | FRONTIERS IN PSYCHIATRY |
出版日期 | 2023-08-29 |
卷号 | 14页码:9 |
通讯作者邮箱 | zhaona@hrbmu.edu.cn (na zhao) ; dr_wangxiaohong@sina.com (xiao hong wang) ; zhangxy@psych.cn.cn (xiang yang zhang) |
ISSN号 | 1664-0640 |
关键词 | major depressive disorder anxiety young risk factor gender differences |
DOI | 10.3389/fpsyt.2023.1218551 |
产权排序 | 5 |
文献子类 | 实证研究 |
英文摘要 | ObjectiveGender differences are prevalent in major depressive disorder (MDD), but the gender differences in the relationship between comorbid anxiety and thyroid hormones in young first-episode and drug-naive (FEND) MDD patients are unknown.MethodsA total of 1,289 young outpatients with FEDN MDD were recruited. Demographic and clinical data were collected for each patient. The patient's blood glucose, blood pressure, thyroid hormone, and thyroid antibody levels were measured. The Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess patients' depression, anxiety, and positive symptoms, respectively.ResultsThe prevalence of comorbid anxiety disorders was 80.4 and 79.4% in male and female MDD patients, respectively. Patients with anxiety had higher HAMD and PANSS scores, higher serum thyroid stimulating hormone (TSH), anti-thyroglobulin antibody (A-TG), and thyroid peroxidase antibody (A-TPO) levels, higher blood glucose and blood pressure levels, and more patients with psychotic symptoms and suicide attempts. Male patients were younger and had a younger age of onset. Logistic regression analysis showed that HAMD score and comorbid suicide attempts were significant predictors of anxiety symptoms in both males and females, whereas A-TG predicted anxiety symptoms in female patients only. Limitations: No causal relationship could be drawn due to the cross-sectional design.ConclusionThis study showed gender differences in factors associated with anxiety symptoms in patients with MDD. Some factors were associated with anxiety symptoms in both male and female patients, while A-TG was only associated with anxiety symptoms in female patients. |
收录类别 | SCI ; SSCI |
WOS关键词 | MENTAL-HEALTH SURVEY ; LATE-LIFE DEPRESSION ; COMORBID ANXIETY ; SEX-DIFFERENCES ; MOOD DISORDERS ; BLOOD-PRESSURE ; RISK-FACTORS ; NONANXIOUS DEPRESSION ; PREVALENCE ; SUICIDE |
资助项目 | Natural Science Foundation of Heilongjiang Province[LH2022H040] ; First Affiliated Hospital of Harbin Medical University[2021B22] |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:001063224100001 |
资助机构 | Natural Science Foundation of Heilongjiang Province ; First Affiliated Hospital of Harbin Medical University |
源URL | [http://ir.psych.ac.cn/handle/311026/46002] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Zhao, Na; Wang, Xiao Hong; Zhang, Xiang Yang |
作者单位 | 1.Harbin Med Univ, Hosp 4, Harbin, Heilongjiang, Peoples R China 2.Harbin Med Univ, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China 3.Qingdao Mental Hlth Ctr, Qingdao, Shandong, Peoples R China 4.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Beijing Municipality, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Ying,Liu, Jia Cheng,Yu, Feng,et al. Gender differences in the association between anxiety symptoms and thyroid hormones in young patients with first-episode and drug na & iuml;ve major depressive disorder[J]. FRONTIERS IN PSYCHIATRY,2023,14:9. |
APA | Zhao, Ying.,Liu, Jia Cheng.,Yu, Feng.,Yang, Li Ying.,Kang, Chuan Yi.,...&Zhang, Xiang Yang.(2023).Gender differences in the association between anxiety symptoms and thyroid hormones in young patients with first-episode and drug na & iuml;ve major depressive disorder.FRONTIERS IN PSYCHIATRY,14,9. |
MLA | Zhao, Ying,et al."Gender differences in the association between anxiety symptoms and thyroid hormones in young patients with first-episode and drug na & iuml;ve major depressive disorder".FRONTIERS IN PSYCHIATRY 14(2023):9. |
入库方式: OAI收割
来源:心理研究所
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