Increased functional connectivity of amygdala subregions in patients with drug-naive panic disorder and without comorbidities
文献类型：期刊论文
| 作者 | Zhang, Ping1,2; Yang, Xiangyun1,2; Wang, Yun1,2; Liu, Huan1,2; Meng, Limin1,2; Yan, Zijun1,2; Zhou, Yuan1,2,3,4 ; Li, Zhanjiang1,2,5,6
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| 刊名 | CHINESE MEDICAL JOURNAL
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| 出版日期 | 2023-06-05 |
| 卷号 | 136期号:11页码:1331-1338 |
| ISSN号 | 0366-6999 |
| 关键词 | Panic disorder Amygdala Resting-state functional magnetic resonance imaging Precuneus |
| DOI | 10.1097/CM9.0000000000002439 |
| 通讯作者 | Li, Zhanjiang(lizhj8@ccmu.edu.cn) |
| 英文摘要 | Background:Amygdala plays an important role in the neurobiological basis of panic disorder (PD), and the amygdala contains different subregions, which may play different roles in PD. The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the amygdala subregions in PD using resting-state functional magnetic resonance imaging and to explore the relationship between the abnormal spontaneous functional connectivity patterns of the regions of interest (ROIs) and the clinical symptoms of PD patients.Methods:Fifty-three drug-naive, non-comorbid PD patients and 70 healthy controls (HCs) were recruited. Seed-based resting-state functional connectivity (rsFC) analyses were conducted using the bilateral amygdalae and its subregions as the ROI seed. Two samples t test was performed for the seed-based Fisher's z-transformed correlation maps. The relationship between the abnormal spontaneous functional connectivity patterns of the ROIs and the clinical symptoms of PD patients was investigated by Pearson correlation analysis.Results:PD patients showed increased rsFC of the bilateral amygdalae and almost all the amygdala subregions with the precuneus/posterior cingulate gyrus compared with the HC group (left amygdala [lAMY]: t = 4.84, P t = 4.55, P t = 3.87, P t = 3.82, P = 0.002; left laterobasal amygdala [lBLA]: t = 4.33, P t = 4.97, P t = 3.26, P = 0.006). The rsFC of the lBLA with the left angular gyrus/inferior parietal lobule remarkably increased in the PD group (t = 3.70, P = 0.003). And most of the altered rsFCs were located in the default mode network (DMN). A significant positive correlation was observed between the severity of anxiety and the rsFC between the lSFA and the left precuneus in PD patients (r = 0.285, P = 0.039).Conclusions:Our research suggested that the increased rsFC of amygdala subregions with DMN plays an important role in the pathogenesis of PD. Future studies may further explore whether the rsFC of amygdala subregions, especially with the regions in DMN, can be used as a biological marker of PD. |
| 收录类别 | SCI |
| WOS关键词 | DEFAULT-MODE NETWORK ; CORTEX ; BRAIN ; PRECUNEUS ; SEVERITY ; FMRI |
| 资助项目 | Capital's Funds for Health Improvement and Research[2020-1-2121] ; Beijing Municipal Science and Technology Commission[Z181100001718077] ; Special Funding of the Beijing Municipal Administration of Hospitals Clinical Medicine Development[ZYLX201815] |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| WOS记录号 | WOS:001000827100007 |
| 资助机构 | Capital's Funds for Health Improvement and Research ; Beijing Municipal Science and Technology Commission ; Special Funding of the Beijing Municipal Administration of Hospitals Clinical Medicine Development |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45455]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Li, Zhanjiang |
| 作者单位 | 1.Capital Med Univ, Beijing Anding Hosp, Dept Clin Psychol, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 5.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Dept Clin Psychol, 5 Ankang Hutong Deshengmen Wai, Beijing 100088, Peoples R China 6.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, 5 Ankang Hutong Deshengmen Wai, Beijing 100088, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ping,Yang, Xiangyun,Wang, Yun,et al. Increased functional connectivity of amygdala subregions in patients with drug-naive panic disorder and without comorbidities[J]. CHINESE MEDICAL JOURNAL,2023,136(11):1331-1338. |
| APA | Zhang, Ping.,Yang, Xiangyun.,Wang, Yun.,Liu, Huan.,Meng, Limin.,...&Li, Zhanjiang.(2023).Increased functional connectivity of amygdala subregions in patients with drug-naive panic disorder and without comorbidities.CHINESE MEDICAL JOURNAL,136(11),1331-1338. |
| MLA | Zhang, Ping,et al."Increased functional connectivity of amygdala subregions in patients with drug-naive panic disorder and without comorbidities".CHINESE MEDICAL JOURNAL 136.11(2023):1331-1338. |
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来源：心理研究所
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