White matter microstructural abnormalities in individuals with attenuated positive symptom syndromes
文献类型：期刊论文
| 作者 | Chen, Zhenzhu1,2,3; Bo, Qijing1,2,3,7; Zhao, Lei1,2,3; Wang, Yimeng1,2,3; Zhang, Zhifang1,2; Zhou, Yuan1,2,5,6 ; Wang, Chuanyue1,2,3,4,7
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| 刊名 | JOURNAL OF PSYCHIATRIC RESEARCH
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| 出版日期 | 2023-07-01 |
| 卷号 | 163页码:150-158 |
| 关键词 | Attenuated positive symptom syndromes Clinical high risk for psychosis Diffusion tensor imaging White matter microstructures Automated fiber quantification |
| ISSN号 | 0022-3956 |
| DOI | 10.1016/j.jpsychires.2023.05.050 |
| 通讯作者 | Bo, Qijing(bqj718@163.com) ; Wang, Chuanyue(wang.cy@163.net) |
| 英文摘要 | White matter (WM) microstructural alterations have been extensively studied in patients with psychosis, but research on the microstructure of WM in individuals with attenuated positive symptom syndrome (APSS) is currently limited. To improve the understanding of the neuropathology in APSS, this study investigated the WM of individuals with APSS using diffusion tensor and T1-weighted imaging. Automated fiber quantification was used to calculate the diffusion index values along the trajectories of 20 major fiber tracts in 42 individuals with APSS and 51 age-and sex-matched healthy control (HC) individuals. The diffusion index values in each of fiber tracts were compared node-by-node between the 2 groups. Compared with the HC group, the APSS group showed differences in the diffusion index values in partial segments of the callosum forceps minor, left and right cingulum cingulate, inferior fronto-occipital fasciculus, right corticospinal tract, left superior longitudinal fasciculus, and arcuate fasciculus. Notably, in the APSS group positive associations were found between the axial diffusivity values of the partial nodes of the left and right cingulum cingulate and the current Global Assessment of Functioning scores, as well as between the axial diffusivity values of the partial nodes of the right corticospinal tract and negative symptoms scores and reasoning and problem-solving scores. These findings suggest that in-dividuals with APSS exhibit reduced WM integrity or possible impaired myelin in certain segments of WM tracts involved in the frontal-and limbic-cortical connections. Additionally, abnormal WM tracts appear to be asso-ciated with impaired general function and neurocognitive function. This study provides important new insights into the neurobiology of APSS and highlights potential targets for future intervention and treatment. |
| 收录类别 | SCI |
| WOS关键词 | ULTRA-HIGH-RISK ; PSYCHOSIS ; SCHIZOPHRENIA ; CONNECTIVITY ; FASCICULUS ; TRACTOGRAPHY ; PATTERNS ; PRODROME |
| 资助项目 | National Natural Science Foundation of China[81901355] ; National Natural Science Foundation of China[81971250] ; General program of Beijing Natural Science Foundation[7192081] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001007212300001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Natural Science Foundation of China ; General program of Beijing Natural Science Foundation |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45581]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Bo, Qijing; Wang, Chuanyue |
| 作者单位 | 1.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China 3.Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders Ctr Schizophrenia, Beijing 100088, Peoples R China 4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China 5.CAS Key Lab Behav Sci, Inst Psychol, Beijing 100101, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 7.Capital Med Univ, Beijing Anding Hosp, 5 Ankang Hutong, Beijing 100088, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zhenzhu,Bo, Qijing,Zhao, Lei,et al. White matter microstructural abnormalities in individuals with attenuated positive symptom syndromes[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2023,163:150-158. |
| APA | Chen, Zhenzhu.,Bo, Qijing.,Zhao, Lei.,Wang, Yimeng.,Zhang, Zhifang.,...&Wang, Chuanyue.(2023).White matter microstructural abnormalities in individuals with attenuated positive symptom syndromes.JOURNAL OF PSYCHIATRIC RESEARCH,163,150-158. |
| MLA | Chen, Zhenzhu,et al."White matter microstructural abnormalities in individuals with attenuated positive symptom syndromes".JOURNAL OF PSYCHIATRIC RESEARCH 163(2023):150-158. |
入库方式： OAI收割
来源：心理研究所
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