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Characteristics of white matter alterations along fibres in patients with bulimia nervosa: A combined voxelwise and tractography study

文献类型：期刊论文

作者Chen, Qian1; Wang, Miao2; Wu, Guo-wei3; Li, Wei-hua1; Ren, Xiao-dan4,5,6; Wang, Yi-ling1; Wei, Xuan1; Wang, Jia-ni1; Yang, Zhenghan1; Li, Xiao-hong4,5,6
刊名EUROPEAN JOURNAL OF NEUROSCIENCE
出版日期2023-07-09
页码14
关键词automated fibre quantification brain white matter bulimia nervosa tract-based spatial statistics voxel-based morphometry
ISSN号0953-816X
DOI10.1111/ejn.16077
通讯作者Tang, Li-rong(tangl_@163.com) ; Zhang, Peng(zpqz1021@foxmail.com) ; Wang, Zhenchang(cjr.wzhch@vip.163.com)
英文摘要Accumulating evidence supports the hypothesis that white matter (WM) abnormalities are involved in the pathophysiology of bulimia nervosa (BN); however, findings from in vivo neuroimaging studies have been inconsistent. We aimed to investigate the possible brain WM alterations, including WM volume and microstructure, in patients with BN. We recruited 43 BN patients and 31 healthy controls (HCs). All participants underwent structural and diffusion tensor imaging. Differences in WM volume and microstructure were evaluated using voxel-based morphometry, tract-based spatial statistics, and automated fibre quantification analysis. Compared with HCs, BN patients showed significantly decreased fractional anisotropy in the middle part of the corpus callosum (nodes 31-32) and increased mean diffusivity in the right cranial nerve V (CN V) (nodes 27-33 and nodes 55-88) and vertical occipital fasciculus (VOF) (nodes 58-85). Moreover, we found decreased axial diffusivity in the right inferior fronto-occipital fasciculus (node 67) and increased radial diffusivity in the CN V (nodes 22-34 and nodes 52-89) and left VOF (nodes 60-66 and nodes 81-85). Meanwhile, WM microstructural changes were correlated with patients' clinical manifestations. We did not find any significant differences in WM volume and the main WM fibre bundle properties between BN patients and HCs. Taken together, these findings provide that BN shows significant brain WM reorganization, but primarily in microstructure (part of WM fibre bundle), which is not sufficient to cause changes in WM volume. The automated fibre quantification analysis could be more sensitive to detect the subtle pathological changes in a point or segment of the WM fibre bundle.
收录类别SCI
WOS关键词ANOREXIA-NERVOSA ; PSYCHOMETRIC PROPERTIES ; EATING-DISORDERS ; CHINESE VERSION ; INTEGRITY ; ABNORMALITIES ; 1ST-EPISODE ; POPULATION ; VALIDATION ; DISSECTION
资助项目National Natural Science Foundation of China[82001790] ; Beijing Hospitals Authority Youth Programme[QML20191902] ; Beijing Friendship Hospital, Capital Medical University[YYZZ201917] ; Beijing Scholars Program[[2015] 160] ; Beijing Key Clinical Discipline Funding[2021-135] ; Beijing Key Laboratory of Mental Disorders[2021JSJB03]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001024404300001
出版者WILEY
资助机构National Natural Science Foundation of China ; Beijing Hospitals Authority Youth Programme ; Beijing Friendship Hospital, Capital Medical University ; Beijing Scholars Program ; Beijing Key Clinical Discipline Funding ; Beijing Key Laboratory of Mental Disorders
源URL[http://ir.psych.ac.cn/handle/311026/45661]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Tang, Li-rong; Zhang, Peng; Wang, Zhenchang
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, Beijing, Peoples R China
2.Chinese Inst Brain Res, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
5.Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
6.Beijing Key Lab Mental Disorders, Beijing, Peoples R China
7.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, 95 Yong Rd, Beijing, Peoples R China
8.Natl Clin Res Ctr Mental Disorders, 5 Ankang Hutong, Beijing, Peoples R China
9.Beijing Key Lab Mental Disorders, 5 Ankang Hutong, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Qian,Wang, Miao,Wu, Guo-wei,et al. Characteristics of white matter alterations along fibres in patients with bulimia nervosa: A combined voxelwise and tractography study[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2023:14.
APA Chen, Qian.,Wang, Miao.,Wu, Guo-wei.,Li, Wei-hua.,Ren, Xiao-dan.,...&Wang, Zhenchang.(2023).Characteristics of white matter alterations along fibres in patients with bulimia nervosa: A combined voxelwise and tractography study.EUROPEAN JOURNAL OF NEUROSCIENCE,14.
MLA Chen, Qian,et al."Characteristics of white matter alterations along fibres in patients with bulimia nervosa: A combined voxelwise and tractography study".EUROPEAN JOURNAL OF NEUROSCIENCE (2023):14.

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来源：心理研究所

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