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Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia

文献类型：期刊论文

作者Huang, Yiru1; Liu, Zitian1; Chen, Zidong1; Zhan, Zongyi4,5; Gao, Le1; Hu, Jingyi1; Wu, Yanyan1; Yan, Fang-Fang2,3; Deng, Daming1; Huang, Chang-Bing2,3,7
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
出版日期2023
卷号64期号:1页码:11
关键词visual crowding strabismus long-term axial misalignment cortical miswiring
ISSN号0146-0404
DOI10.1167/iovs.64.1.10
通讯作者Huang, Chang-Bing(huangcb@psych.ac.cn) ; Yu, Minbin(yuminbin@mail.sysu.edu.cn)
英文摘要PURPOSE. Inspired by physiological and neuroimaging findings that revealed squint-induced modification of cortical volume and visual receptive field in early visual areas, we hypothesized that strabismic eyes without amblyopia manifest an increase in critical spacing of visual crowding, an essential bottleneck on object recognition and reliable psychophysical index of cortical organization. METHODS. We used real-time eye tracking to ensure gaze-contingent display and examined visual crowding in patients with horizontal concomitant strabismus (both esotropia and exotropia) but without amblyopia and age-matched normal controls. RESULTS. Nineteen patients with exotropia (12 men, mean & PLUSMN; SD = 22.89 & PLUSMN; 7.82 years), 21 patients with esotropia (10 men, mean & PLUSMN; SD = 23.48 & PLUSMN; 6.95 years), and 14 age-matched normal controls (7 men, mean & PLUSMN; SD = 23.07 & PLUSMN; 1.07 years) participated in this study. We found that patients with strabismus without amblyopia showed significantly larger critical spacing with nasotemporal asymmetry in only the radial axis that related to the strabismus pattern, with exotropia exhibiting stronger temporal hemifield crowding and esotropia exhibiting stronger nasal hemifield crowding, in both the deviated and fixating eyes. Moreover, the magnitude of crowding change was related to the duration and degree of strabismic deviation. CONCLUSIONS. Using visual crowding as a psychophysical index of cortical organization, our study demonstrated significantly greater peripheral visual crowding with nasotem-poral asymmetry in only the radial axis in patients with strabismus without amblyopia, indicating the existence of hemifield-and axis-specific miswiring of cortical processing in object recognition induced by long-term adaptation to ocular misalignment.
收录类别SCI
WOS关键词OBJECT RECOGNITION ; OCULAR DOMINANCE ; PERCEPTION ; VISION ; ACUITY ; RESOLUTION ; CORTEX ; SHAPE ; EYE
资助项目Natural Science Foundation Team Project of Guangdong Province Grant[2015A030312016] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110479] ; Natural Science Foundation of China[NSFC 32100864] ; Natural Science Foundation of China[NSFC 32071056]
WOS研究方向Ophthalmology
语种英语
WOS记录号WOS:001043015700005
出版者ASSOC RESEARCH VISION OPHTHALMOLOGY INC
资助机构Natural Science Foundation Team Project of Guangdong Province Grant ; Guangdong Basic and Applied Basic Research Foundation ; Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/45905]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Huang, Chang-Bing; Yu, Minbin
作者单位1.Sun Yat sen Univ, Zhongshan Ophthalm Ctr, Guangdong Prov Clin Res Ctr Ocular Dis, State Key Lab Ophthalmol,Guangdong Prov Key Lab Op, Guangzhou, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Jinan Univ, Shenzhen Eye Hosp, Shenzhen Eye Inst, Shenzhen, Peoples R China
5.Shenzhen Univ, Sch Optometry, Shenzhen, Peoples R China
6.Sun Yat sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou, Guangdong, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Yiru,Liu, Zitian,Chen, Zidong,et al. Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2023,64(1):11.
APA Huang, Yiru.,Liu, Zitian.,Chen, Zidong.,Zhan, Zongyi.,Gao, Le.,...&Yu, Minbin.(2023).Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,64(1),11.
MLA Huang, Yiru,et al."Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 64.1(2023):11.

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来源：心理研究所

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