Cortical Reorganization After Optical Alignment in Strabismic Patients Outside of Critical Period
文献类型：期刊论文
| 作者 | Huang, Yiru1; Liu, Zitian1; Wang, Mingqin1; Gao, Le1; Wu, Yanyan1; Hu, Jingyi1; Zhang, Zhenyu2,3 ; Yan, Fang-Fang2,3; Deng, Daming1; Huang, Chang-Bing2,3
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| 刊名 | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
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| 出版日期 | 2023-08-01 |
| 卷号 | 64期号:11页码:13 |
| ISSN号 | 0146-0404 |
| 关键词 | visual crowding strabismus axial alignment cortical reorganization |
| DOI | 10.1167/iovs.64.11.5 |
| 通讯作者 | Huang, Chang-Bing(huangcb@psych.ac.cn) ; Yu, Minbin(yuminbin@mail.sysu.edu.cn) |
| 英文摘要 | PURPOSE. To measure visual crowding, an essential bottleneck on object recognition and reliable psychophysical index of cortex organization, in older children and adults with horizontal concomitant strabismus before and after strabismus surgery. METHODS. Using real-time eye tracking to ensure gaze-contingent display, we examined the peripheral visual crowding effects in older children and adults with horizontal concomitant strabismus but without amblyopia before and after strabismus surgery. Patients were asked to discriminate the orientation of the central tumbling E target letter with flankers arranged along the radial or tangential axis in the nasal or temporal hemifield at different eccentricities (5 degrees or 10 degrees). The critical spacing value, which is the minimum space between the target and the flankers required for correct discrimination, was obtained for comparisons before and after strabismus surgery. RESULTS. Twelve individuals with exotropia (6 males, 21.75 +/- 7.29 years, mean +/- SD) and 15 individuals with esotropia (6 males, 24.13 +/- 5.96 years) participated in this study. We found that strabismic individuals showed significantly larger critical spacing with nasotemporal asymmetry along the radial axis that related to the strabismus pattern, with exotropes exhibiting stronger temporal field crowding and esotropes exhibiting stronger nasal field crowding before surgical alignment. After surgery, the critical spacing was reduced and rebalanced between the nasal and temporal hemifields. Furthermore, the postoperative recovery of stereopsis was associated with the extent of nasotemporal balance of critical spacing. CONCLUSIONS. We find that optical realignment (i.e., strabismus surgery) can normalize the enlarged visual crowding effects, a reliable psychophysical index of cortical organization, in the peripheral visual field of older children and adults with strabismus and rebalance the nasotemporal asymmetry of crowding, promoting the recovery of postoperative stereopsis. Our results indicated a potential of experience-dependent cortical organization after axial alignment even for individuals who are out of the critical period of visual development, illuminating the capacity and limitations of optics on sensory plasticity and emphasizing the importance of ocular correction for clinical practice. |
| 收录类别 | SCI |
| WOS关键词 | QUALITY-OF-LIFE ; OBJECT RECOGNITION ; OCULAR DOMINANCE ; PERCEPTION ; PARAFOVEAL ; PLASTICITY ; AMBLYOPIA ; VISION ; IMPACT ; ADULTS |
| 资助项目 | Natural Science Foundation of China[NSFC 32071056] ; Natural Science Foundation of China[NSFC 32100864] ; Natural Science Foundation of China[NSFC 82271115] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515011829] |
| WOS研究方向 | Ophthalmology |
| 语种 | 英语 |
| 出版者 | ASSOC RESEARCH VISION OPHTHALMOLOGY INC |
| WOS记录号 | WOS:001051169500005 |
| 资助机构 | Natural Science Foundation of China ; Guangdong Basic and Applied Basic Research Foundation |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45917]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Huang, Chang-Bing; Yu, Minbin |
| 作者单位 | 1.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangdong Prov Clin Res Ctr Ocular Dis, State Key Lab Ophthalmol,Guangdong Prov Key Lab O, Guangzhou, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yiru,Liu, Zitian,Wang, Mingqin,et al. Cortical Reorganization After Optical Alignment in Strabismic Patients Outside of Critical Period[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2023,64(11):13. |
| APA | Huang, Yiru.,Liu, Zitian.,Wang, Mingqin.,Gao, Le.,Wu, Yanyan.,...&Yu, Minbin.(2023).Cortical Reorganization After Optical Alignment in Strabismic Patients Outside of Critical Period.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,64(11),13. |
| MLA | Huang, Yiru,et al."Cortical Reorganization After Optical Alignment in Strabismic Patients Outside of Critical Period".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 64.11(2023):13. |
入库方式： OAI收割
来源：心理研究所
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