Fronto-temporal dysfunction in appetitive regulation of bulimia nervosa with affective disorders: A regional homogeneity and remote connectivity pattern analysis
文献类型:期刊论文
作者 | Wang, Jiani1; Tang, Lirong2,3; Wang, Miao4; Wu, Guowei5; Li, Weihua1; Wang, Yiling1; Wang, Xuemei2,3; Wang, Hao1; Yang, Zhenghan1; Li, Zhanjiang2,3 |
刊名 | JOURNAL OF AFFECTIVE DISORDERS |
出版日期 | 2023-11-01 |
卷号 | 340页码:280-289 |
通讯作者邮箱 | chenqian8319@163.com (q. chen) ; zpqz1021@foamail.com (p. zhang) ; cjr.cvzhch@vip.163.com (z. wang) |
ISSN号 | 0165-0327 |
关键词 | Regional homogeneity based on Kendall's coefficient of concordance Functional connectivity Bulimia nervosa Affective disorders Frontal-temporal regions |
DOI | 10.1016/j.jad.2023.08.036 |
产权排序 | 4 |
文献子类 | 实证研究 |
英文摘要 | Objective: The aim of this study was to assess brain functional alterations in BN patients with affective disorders and their association with maladaptive eating behaviors. Methods: A total of 42 BN patients with affective disorders (anxiety and depression) and 47 healthy controls (HCs) were enrolled in this study. The resting-state fMRI data were analyzed for functional changes as indicated by regional homogeneity based on Kendall's coefficient of concordance (KCC-ReHo) and seed-based functional connectivity (FC). A principal component analysis (PCA) model was used to identify the commonalities within the behavioral questionnaires from the BN group. Results: Patients in the BN group showed decreased ReHo in the bilateral middle frontal gyrus (MFG) and right supramarginal gyrus (SMG). Additionally, the BN group showed increased FC between the left MFG and the right inferior temporal gyrus (ITG); decreased FC between the right MFG and the bilateral insula and the left middle temporal gyrus (MTG); and decreased FC between the right SMG and the left superior temporal gyrus (STG) and right inferior frontal gyrus (IFG). In the FC-behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the left MFG and the right ITG. Conclusion: Based on a brain functional analysis (ReHo and FC), this study revealed significant aberrant changes in the frontal-temporal regions of BN patients with affective disorders. These regions, which serve as frontotemporal circuitry, are associated with restraint and emotional eating behaviors. Our findings shed new light on the neural mechanisms underlying the condition. |
收录类别 | SCI |
WOS关键词 | DUTCH EATING BEHAVIOR ; ANOREXIA-NERVOSA ; PSYCHOMETRIC PROPERTIES ; QUESTIONNAIRE DEBQ ; EMOTION REGULATION ; NEURAL SYSTEMS ; RISK ; INDIVIDUALS ; COMORBIDITY ; MODEL |
资助项目 | National Natural Science Foundation of China[82001790] ; Beijing Hospitals Authority Youth Programme[QML20191902] ; Beijing Friendship Hospital, Capital Medical University[YYZZ201917] ; Beijing Scholar 2015 (Zhenchang Wang) , Beijing key Clinical Discipline Funding[2021-135] ; Beijing Key Laboratory of Mental Disorders[2021JSJB03] ; postdoctoral launch project of Beijing Friendship Hospital, Capital Medical University[yybsh2022003] |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:001057449600001 |
资助机构 | National Natural Science Foundation of China ; Beijing Hospitals Authority Youth Programme ; Beijing Friendship Hospital, Capital Medical University ; Beijing Scholar 2015 (Zhenchang Wang) , Beijing key Clinical Discipline Funding ; Beijing Key Laboratory of Mental Disorders ; postdoctoral launch project of Beijing Friendship Hospital, Capital Medical University |
源URL | [http://ir.psych.ac.cn/handle/311026/45923] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Chen, Qian; Zhang, Peng; Wang, Zhenchang |
作者单位 | 1.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, 95 Yong An Rd, Beijing, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 3.Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China 4.Chinese Inst Brain Res, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Jiani,Tang, Lirong,Wang, Miao,et al. Fronto-temporal dysfunction in appetitive regulation of bulimia nervosa with affective disorders: A regional homogeneity and remote connectivity pattern analysis[J]. JOURNAL OF AFFECTIVE DISORDERS,2023,340:280-289. |
APA | Wang, Jiani.,Tang, Lirong.,Wang, Miao.,Wu, Guowei.,Li, Weihua.,...&Wang, Zhenchang.(2023).Fronto-temporal dysfunction in appetitive regulation of bulimia nervosa with affective disorders: A regional homogeneity and remote connectivity pattern analysis.JOURNAL OF AFFECTIVE DISORDERS,340,280-289. |
MLA | Wang, Jiani,et al."Fronto-temporal dysfunction in appetitive regulation of bulimia nervosa with affective disorders: A regional homogeneity and remote connectivity pattern analysis".JOURNAL OF AFFECTIVE DISORDERS 340(2023):280-289. |
入库方式: OAI收割
来源:心理研究所
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