Preparation of poly (ethylene glycol) acrylate grafted polystyrene resin for solid-phase peptide synthesis
文献类型：期刊论文
| 作者 | Zhang, Rongyue; Li, Qiang; Zhang, Jing; Li, Juan; Ma, Guanghui; Su, Zhiguo |
| 刊名 | REACTIVE & FUNCTIONAL POLYMERS
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 72期号:10页码:773-780 |
| 关键词 | High loading Solid phase peptide synthesis Atom transfer radical polymerization Graft |
| ISSN号 | 1381-5148 |
| 通讯作者 | Ma, GH |
| 英文摘要 | The solid-phasesynthesisresin with high loading capacity was prepared through grafting poly (ethyleneglycol) acrylate monomer from Merrifield resins via activators generated by electron transfer atom transfer radical polymerization. The graftedresins demonstrate well-swellability in both polar and nonpolar solvent such as dichloromethane, dimethylformamide, ethanol, tetrahydrofuran, acetonitrile, methanol and water. Particularly, the swelling ability of the graftedresin has reached two-fold of Merrifield resin in the polar solvent such as acetonitrile, methanol and water, and it enable high functional loadings up to 0.51.2 mmol g(-1) compared with the conventional polystyrene-grafting-poly (ethyleneglycol) (0.150.25 mmol g(-1)). This resin was derived to be used for synthesis of a difficult sequence-acyl carrier protein fragment 65-74 (ACP 65-74). The quantity and purity of peptide obtained from the graftedresin were higher than when the commercial Wang resin was used. The synthesis efficiency enhanced with the increase of grafting chains length within the range of hydroxyl capacity at 0.51.0 mmol g-1. It was relative that the longer grafting chains were favor to suppress the hydrophobicity of the Merrifield resin. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Applied ; Engineering, Chemical ; Polymer Science |
| 研究领域[WOS] | Chemistry ; Engineering ; Polymer Science |
| 关键词[WOS] | TRANSFER RADICAL POLYMERIZATION ; SUPPORTS ; ATRP ; MONOLITH ; BEADS ; AIR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309096400015 |
| 公开日期 | 2013-10-11 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3183]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Rongyue,Li, Qiang,Zhang, Jing,et al. Preparation of poly (ethylene glycol) acrylate grafted polystyrene resin for solid-phase peptide synthesis[J]. REACTIVE & FUNCTIONAL POLYMERS,2012,72(10):773-780. |
| APA | Zhang, Rongyue,Li, Qiang,Zhang, Jing,Li, Juan,Ma, Guanghui,&Su, Zhiguo.(2012).Preparation of poly (ethylene glycol) acrylate grafted polystyrene resin for solid-phase peptide synthesis.REACTIVE & FUNCTIONAL POLYMERS,72(10),773-780. |
| MLA | Zhang, Rongyue,et al."Preparation of poly (ethylene glycol) acrylate grafted polystyrene resin for solid-phase peptide synthesis".REACTIVE & FUNCTIONAL POLYMERS 72.10(2012):773-780. |
入库方式： OAI收割
来源：过程工程研究所
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