COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery
文献类型：期刊论文
| 作者 | Xing, Chen1,2 ; Ma, Jing-Chao1,2; Yun, Han-Qi1,2; Liu, Qing-Jing1,2; Chang, Xiao-Yue1,2; Wang, Yan-Qing1,2; Zhou, Wen1,2,3
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| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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| 出版日期 | 2023-06-01 |
| 卷号 | 50期号:6页码:1245-1260 |
| ISSN号 | 1000-3282 |
| 关键词 | COVID-19 olfactory dysfunction SARS-CoV-2 SARS-CoV-2 variants long COVID olfactory training |
| DOI | 10.16476/j.pibb.2023.0055 |
| 通讯作者 | Zhou, Wen(zhouw@psych.ac.cn) |
| 英文摘要 | Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since olfactory dysfunction is the main neurological symptom of COVID-19, it is important to examine the prevalence, underlying mechanisms, and recovery trajectories of COVID-19-related olfactory dysfunction for the promotion of public health. Reported prevalence rates of COVID19-related olfactory dysfunction vary widely across studies due to differences in the assessment of olfactory function, demographic background, and the predominant SARS-CoV-2 strains around the time of data collection. Specifically, different SARS-CoV-2 strains differ in the stability of spike glycoproteins and the host-cell infection pathways and thus efficacy in infecting the olfactory epithelium. In general, SARS-CoV-2 has been shown to cause inflammatory obstruction of the olfactory cleft, death of supporting cells, and host immune responses in the olfactory epithelium. Whether and how it invades into the central olfactory system remain controversial. Some individuals with "long COVID" suffer from chronic olfactory loss. The pathological mechanisms likely involve persistent inflammation in the olfactory epithelium and disruption of its regeneration triggered by SARS-CoV-2 infection. Based on the olfactory vector hypothesis, SARS-CoV-2 may affect central nervous system function by way of the olfactory system and could potentially induce neurodegeneration in the long term. Available interventions for managing olfactory dysfunction from SARS-CoV-2 infection include olfactory training and pharmacotherapy. |
| 收录类别 | SCI |
| WOS关键词 | NEURODEGENERATIVE DISEASE ; SARS-COV-2 INFECTION ; EPITHELIUM ; ROUTE |
| 资助项目 | Chinese Academy of Sciences[JCTD-2021-06] ; Institute of Psychology, Chinese Academy of Sciences[E0CX412008] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| WOS记录号 | WOS:001021794700003 |
| 资助机构 | Chinese Academy of Sciences ; Institute of Psychology, Chinese Academy of Sciences |
| 源URL | [http://ir.psych.ac.cn/handle/311026/45800]  |
| 专题 | 心理研究所_脑与认知科学国家重点实验室 |
| 通讯作者 | Zhou, Wen |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Chinese Inst Brain Res, Beijing 102206, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Chen,Ma, Jing-Chao,Yun, Han-Qi,et al. COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2023,50(6):1245-1260. |
| APA | Xing, Chen.,Ma, Jing-Chao.,Yun, Han-Qi.,Liu, Qing-Jing.,Chang, Xiao-Yue.,...&Zhou, Wen.(2023).COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,50(6),1245-1260. |
| MLA | Xing, Chen,et al."COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 50.6(2023):1245-1260. |
入库方式： OAI收割
来源：心理研究所
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