Combinatorial synthesis and screening of uniform molecularly imprinted microspheres for chloramphenicol using microfluidic device
文献类型：期刊论文
| 作者 | Liu, Xingyong2; Lei, Jiandu1 |
| 刊名 | POLYMER ENGINEERING AND SCIENCE
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 52期号:10页码:2099-2105 |
| 关键词 | POLYMER BEADS CHROMATOGRAPHY SILICA PHASE HPLC |
| ISSN号 | 0032-3888 |
| 通讯作者 | Lei, JD |
| 英文摘要 | A novel method for combinatorial synthesis and screening of uniform-size molecularly imprinted microspheres using a microfluidic device is presented, in which a new microfluidic device containing twelve pairs of shape microchannels is designed to produce droplets and imprinted microspheres via controlled suspension polymerization. This technique combines molecular imprinting and microfluidic device with the combinatorial chemical approach, allowing rapid screening and optimization of uniform imprinted microspheres. On the example of chloramphenicol (CAP), the imprinted microspheres of CAP were prepared by a combinatorial approach using water with 1.5% polyvinyl alcohol as continuous phase, and ethyl acetatechloroform (4:1, v/v) as porogenic solvents. Functional monomers methacrylic acid (MAA), 4-vinylpyridine or acrylamide were screened, and the molar ratio of template molecule to functional monomer was optimized. The results indicate that MAA is the best functional monomer for imprinting of CAP, and when the molar ratio of CAP to MAA is 1:5, the imprinted microspheres exhibit the best imprinting performance, and have good monodispersity and selectivity. This combinatorial protocol is well suited for fast and efficient screening and optimization of synthesis for uniform imprinted microspheres because 12 kinds of imprinting conditions can be performed simultaneously in this microfluidic device. POLYM. ENG. SCI., 2012. (C) 2012 Society of Plastics Engineers |
| WOS标题词 | Science & Technology ; Technology ; Physical Sciences |
| 类目[WOS] | Engineering, Chemical ; Polymer Science |
| 研究领域[WOS] | Engineering ; Polymer Science |
| 关键词[WOS] | POLYMER BEADS ; CHROMATOGRAPHY ; SILICA ; PHASE ; HPLC |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308880300006 |
| 公开日期 | 2013-10-11 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/3192]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Sichuan Univ Sci & Engn, Sch Mat & Chem Engn, Zigong 643000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xingyong,Lei, Jiandu. Combinatorial synthesis and screening of uniform molecularly imprinted microspheres for chloramphenicol using microfluidic device[J]. POLYMER ENGINEERING AND SCIENCE,2012,52(10):2099-2105. |
| APA | Liu, Xingyong,&Lei, Jiandu.(2012).Combinatorial synthesis and screening of uniform molecularly imprinted microspheres for chloramphenicol using microfluidic device.POLYMER ENGINEERING AND SCIENCE,52(10),2099-2105. |
| MLA | Liu, Xingyong,et al."Combinatorial synthesis and screening of uniform molecularly imprinted microspheres for chloramphenicol using microfluidic device".POLYMER ENGINEERING AND SCIENCE 52.10(2012):2099-2105. |
入库方式： OAI收割
来源：过程工程研究所
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