A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility
文献类型：期刊论文
| 作者 | Peng, Wenpeng2,4,5; Chen, Yizhe3; Fan, Hongde3; Chen, Shanshan1; Wang, Hui3; Song, Xiang4,5 |
| 刊名 | MATERIALS
 |
| 出版日期 | 2023 |
| 卷号 | 16期号:2页码:19 |
| 关键词 | biodegradable magnesium alloys poly-l-lactic acid hydrofluoric acid degradation biocompatibility |
| DOI | 10.3390/ma16020682 |
| 通讯作者 | Song, Xiang(song761231@sina.com) |
| 英文摘要 | Problems of rapid degradation and poor biocompatibility (endothelialization and hemocompatibility) limit magnesium (Mg) alloy's further applications in vascular stents. To solve these problems, a novel composite coating was designed on Mg alloy via a two-step method. First, a Mg alloy sample was immersed in hydrofluoric acid. Then, a poly-l-lactic acid (PLLA) coating was made by ultrasonic atomization spraying with 5 and 10 layers (referred to as PLLA(5)-HF-Mg and PLLA(10)-HF-Mg). Characterizations were analyzed from the microstructure, element distribution, and wettability. The degradation behavior was tested with an electrochemical test and immersion test. Endothelialization was investigated using human umbilical vein endothelial cells (HUVECs). Hemocompatibility was examined with a platelet adhesion test. The results showed that the PLLA coating could not only cover the surface, but also could permeate through and cover the holes on the MgF2 layer, mechanically locked with the substrate. Thus, the composite coating had higher corrosion resistance. The PLLA/MgF2 coating, especially on PLLA(10)-HF-Mg, enhanced HUVECs' viability and growth. While incubated with platelets, the PLLA/MgF2 coating, especially on PLLA(10)-HF-Mg, had the lowest platelet adhesion number and activity. Taken together, the novel PLLA/MgF2 coating controls Mg alloy's degradation by spraying different layers of PLLA, resulting in better endothelialization and hemocompatibility, providing a promising candidate for cardiovascular stents. |
| 资助项目 | National Natural Science Foundation Council of China[52175360] ; National Natural Science Foundation Council of China[51901227] ; Young Elite Scientists Sponsorship Program by CAST[2021QNRC001] ; China Postdoctoral Science Foundation[2022T150278] ; China Postdoctoral Science Foundation[2022M710062] |
| WOS研究方向 | Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000916128700001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation Council of China ; Young Elite Scientists Sponsorship Program by CAST ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.imr.ac.cn/handle/321006/175344]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Song, Xiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China 3.Wuhan Univ Technol, Hubei Key Lab Adv Technol Automot Components, Wuhan 430070, Peoples R China 4.Harbin Med Univ, Affiliated Hosp 4, Cardiovasc Ctr, Harbin 150000, Peoples R China 5.Harbin Med Univ, Dept Clin Med, Harbin 150000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Wenpeng,Chen, Yizhe,Fan, Hongde,et al. A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility[J]. MATERIALS,2023,16(2):19. |
| APA | Peng, Wenpeng,Chen, Yizhe,Fan, Hongde,Chen, Shanshan,Wang, Hui,&Song, Xiang.(2023).A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility.MATERIALS,16(2),19. |
| MLA | Peng, Wenpeng,et al."A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility".MATERIALS 16.2(2023):19. |
入库方式： OAI收割
来源：金属研究所
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