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Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing

文献类型：期刊论文

作者Wang, Ning1; Yang, Shude1,3; Shi, Huixin1; Song, Yiping1; Sun, Hui3; Wang, Qiang3; Tan, Lili2; Guo, Shu1
刊名JOURNAL OF MAGNESIUM AND ALLOYS
出版日期2022-12-01
卷号10期号:12页码:3327-3353
关键词Magnesium alloys Bone regeneration Immunomodulation Angiogenesis Osteogenesis
ISSN号2213-9567
DOI10.1016/j.jma.2022.11.014
通讯作者Wang, Qiang(mfqwang@cmu.edu.cn) ; Tan, Lili(lltan@imr.ac.cn) ; Guo, Shu(sguo@cmu.edu.cn)
英文摘要Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated to the researches on the composition design, preparation and processing, surface modification, the degradation modes of Mg alloys. Nevertheless, the mechanisms by which Mg alloys promote bone healing remain elusive. This review gives an account of specific mechanisms on Mg alloys promoting bone healing from four aspects, immunomodulatory, angiogenesis, osteogenesis and regulation of osteoclast function. We highlight the regulation of Mg alloys on the functional status and interactions of numerous cells that are involved in bone healing, including immune cells, osteogenic-related cells, osteoclasts, endothelial cells (ECs), nerve cells, etc., and summarize the signaling pathways involved, with the aim to provide the basis and support on future investigation on mechanisms on Mg alloys driving bone regeneration. More importantly, it provides a rationale and a general new basis for the application of Mg alloys in orthopedic fields. (c) 2022 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
资助项目National Key Research and Development Program of China[2020YFC1107501] ; National Natural Science Foundation of China[51971222] ; STS program[20201600200042] ; DongGuan Innovative Research Team Program ; Natural Science Foundation of Liaoning Province[2021-BS-103] ; China Postdoctoral Science Foundation[2020M681020]
WOS研究方向Metallurgy & Metallurgical Engineering
语种英语
WOS记录号WOS:000911252800003
出版者KEAI PUBLISHING LTD
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; STS program ; DongGuan Innovative Research Team Program ; Natural Science Foundation of Liaoning Province ; China Postdoctoral Science Foundation
源URL[http://ir.imr.ac.cn/handle/321006/175381]  
专题金属研究所_中国科学院金属研究所
通讯作者Wang, Qiang; Tan, Lili; Guo, Shu
作者单位1.China Med Univ, Dept Plast Surg, Hosp 1, 115 Nanjing North St, Shenyang 110001, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
3.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, 117 Nanjing North St, Shenyang 110001, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Ning,Yang, Shude,Shi, Huixin,et al. Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing[J]. JOURNAL OF MAGNESIUM AND ALLOYS,2022,10(12):3327-3353.
APA Wang, Ning.,Yang, Shude.,Shi, Huixin.,Song, Yiping.,Sun, Hui.,...&Guo, Shu.(2022).Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing.JOURNAL OF MAGNESIUM AND ALLOYS,10(12),3327-3353.
MLA Wang, Ning,et al."Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing".JOURNAL OF MAGNESIUM AND ALLOYS 10.12(2022):3327-3353.

入库方式： OAI收割

来源：金属研究所

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