Spontaneous Vesicle Formation of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymer
文献类型：期刊论文
| 作者 | Chen, Shu; Yang, Bin; Guo, Chen; Ma, Jun-He; Yang, Liang-Rong; Liang, Xiangfeng; Hua, Chao; Liu, Hui-Zhou |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2008-12-11 |
| 卷号 | 112期号:49页码:15659-15665 |
| 关键词 | sodium dodecyl-sulfate peo block-copolymers pluronic f127 eo97po69eo97 aqueous-solutions aggregation behavior ionic surfactants drug-delivery polymer vesicles temperature micellization |
| ISSN号 | 1520-6106 |
| 其他题名 | J. Phys. Chem. B |
| 中文摘要 | A novel method has been developed to prepare vesicles from aqueous solutions of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, by adding anionic surfactant sodium dodecyl sulfate (SDS) and inorganic salt NaF. As determined by TEM and dynamic light scattering (DLS) measurements, the average diameter of vesicles is about 800 nm having 50 nm outer shell thickness. Identifying hydrophobic interactions between the block copolymers and the microenvironments around the vesicles using FTIR, (1)H NMR, and fluorescence spectroscopy techniques revealed the vesicle formation mechanism. The spontaneously formed vesicles were further cross-linked by converting the terminal hydroxyl groups of block copolymers into aldehydes, and then chemically bridging the polymer chains by the reaction between aldehydes and diamine compounds. The cross-linked vesicles are proved much more stable than free vesicles even at higher dilutions. The obtained vesicles with good stability and biocompatibility are promising candidates for widespread applications. |
| 英文摘要 | A novel method has been developed to prepare vesicles from aqueous solutions of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, by adding anionic surfactant sodium dodecyl sulfate (SDS) and inorganic salt NaF. As determined by TEM and dynamic light scattering (DLS) measurements, the average diameter of vesicles is about 800 nm having 50 nm outer shell thickness. Identifying hydrophobic interactions between the block copolymers and the microenvironments around the vesicles using FTIR, (1)H NMR, and fluorescence spectroscopy techniques revealed the vesicle formation mechanism. The spontaneously formed vesicles were further cross-linked by converting the terminal hydroxyl groups of block copolymers into aldehydes, and then chemically bridging the polymer chains by the reaction between aldehydes and diamine compounds. The cross-linked vesicles are proved much more stable than free vesicles even at higher dilutions. The obtained vesicles with good stability and biocompatibility are promising candidates for widespread applications. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SODIUM DODECYL-SULFATE ; PEO BLOCK-COPOLYMERS ; PLURONIC F127 EO97PO69EO97 ; AQUEOUS-SOLUTIONS ; AGGREGATION BEHAVIOR ; IONIC SURFACTANTS ; DRUG-DELIVERY ; POLYMER VESICLES ; TEMPERATURE ; MICELLIZATION |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000261426500018 |
| 公开日期 | 2013-10-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/2725]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Lab Separat Sci & Engn, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shu,Yang, Bin,Guo, Chen,et al. Spontaneous Vesicle Formation of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymer[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(49):15659-15665. |
| APA | Chen, Shu.,Yang, Bin.,Guo, Chen.,Ma, Jun-He.,Yang, Liang-Rong.,...&Liu, Hui-Zhou.(2008).Spontaneous Vesicle Formation of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymer.JOURNAL OF PHYSICAL CHEMISTRY B,112(49),15659-15665. |
| MLA | Chen, Shu,et al."Spontaneous Vesicle Formation of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymer".JOURNAL OF PHYSICAL CHEMISTRY B 112.49(2008):15659-15665. |
入库方式： OAI收割
来源：过程工程研究所
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