Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers
文献类型：期刊论文
| 作者 | Guo, Feng1,2; Han, Rizheng1,2; Ying, Jishan1,2; Zhang, Zeping1,2; Yang, Rui1,2; Zhang, Xing1,2 |
| 刊名 | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2023-05-01 |
| 卷号 | 144页码:178-187 |
| ISSN号 | 1005-0302 |
| 关键词 | Polymeric heart valve Anisotropy Cellulose fibers Polyurethane |
| DOI | 10.1016/j.jmst.2022.09.063 |
| 通讯作者 | Zhang, Xing(xingzhang@imr.ac.cn) |
| 英文摘要 | In this work, bioinspired anisotropic polymeric heart valves were fabricated using composite materials from polyurethane (PU) and natural cellulose fiber bundles. Cellulose fibers with good alignment were obtained from balsa wood by a top-down process, which were then distributed in polyurethane to pre-pare cellulose fiber bundles reinforced polyurethane (CPU) by hot pressing. The storage modulus of the CPU along the direction parallel to the fiber alignment was 16.70 +/- 0.80 MPa, whereas that along the direction perpendicular to the fiber alignment was 8.41 +/- 0.94 MPa by dynamic mechanical analysis (DMA) tests at 1 Hz, comparable to aortic valve leaflets. Moreover, 2-methacryloyloxyethyl phosphoryl-choline (MPC) was grafted onto the CPU surface (CPU-MPC) to improve hemocompatibility. With MPC modification, the water contact angle decreased significantly from 54.58 degrees +/- 2.98 degrees to 26.42 degrees +/- 3.50 degrees, and the platelet adhesion was reduced by 92%, compared to the original CPU. In vitro cell culture proved that both CPU and CPU-MPC samples did not show any cytotoxicity. Furthermore, the CPU composites were used to fabricate polymeric heart valves, which showed excellent hydrodynamic performance with a large orifice area (1.70 cm2) and low regurgitation fraction (0.7%), meeting the requirements of ISO 5840-2 standard.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science &Technology. |
| 资助项目 | National Key Re-search and Development Program ; National Natural Science Foundation of China ; [2018YFC1105503] ; [31670981] |
| WOS研究方向 | Materials Science ; Metallurgy & Metallurgical Engineering |
| 语种 | 英语 |
| 出版者 | JOURNAL MATER SCI TECHNOL |
| WOS记录号 | WOS:000901716800005 |
| 资助机构 | National Key Re-search and Development Program ; National Natural Science Foundation of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/175681]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhang, Xing |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Feng,Han, Rizheng,Ying, Jishan,et al. Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2023,144:178-187. |
| APA | Guo, Feng,Han, Rizheng,Ying, Jishan,Zhang, Zeping,Yang, Rui,&Zhang, Xing.(2023).Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,144,178-187. |
| MLA | Guo, Feng,et al."Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 144(2023):178-187. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。