Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation
文献类型：期刊论文
| 作者 | Erisen, Deniz Eren1,2; Gu, Guisong2,3; Chen, Shanshan2; Yang, Ke2; Zhang, Bingchun2; Shen, Minggang3 |
| 刊名 | MATERIALS RESEARCH EXPRESS
 |
| 出版日期 | 2022-12-01 |
| 卷号 | 9期号:12页码:8 |
| 关键词 | biomedical materials copper chitosan cytotoxicity |
| DOI | 10.1088/2053-1591/acad67 |
| 通讯作者 | Erisen, Deniz Eren(deniz17b@imr.ac.cn) ; Chen, Shanshan(sschen@imr.ac.cn) |
| 英文摘要 | Background: Catheters are polymeric materials frequently used in clinics and are associated with the risk of inflammation and coagulation. The development of bioactive catheter surfaces is worth applying because antibiotic resistance in bacterial infections is common. Copper (Cu) ion coordinated chitosan (Chitosan-Cu) coatings on medical catheters, and several studies have recently approved its application. Objective: It is crucial to investigate the possible cytotoxicity of Chitosan-Cu coatings on surrounding cells. Methods: The effect of the Chitosan-Cu complex coating, proven to have bioactive activities at different rates on L929 cells, was examined by the CCK-8 test kit. In 24 h, the cell viabilities of samples, with Chitosan: Cu ratios of 10:0, 10:1, 50:1, and 100:1, were measured as 105.14%, 89.90%, 91.91%, and 100.75%, respectively. In 72 h, they were measured at 119.45%, 109.33%, 110.24%, and 114.45%. The surface morphology of the coating was characterized by electron microscopy, and the entity of the Cu ions in the coating was characterized by x-ray photoelectron spectroscopy. Conclusion: Cytotoxicity assays showed that Cu, with a maximum concentration of 10% by volume, showed no toxic behavior. |
| 资助项目 | National Key Research and Development Program of China ; National Natural Science Foundation of China[2018YFC1105504] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[51901227] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[81701048] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[81873918] ; Doctoral StartupFund of Liaoning Province[2019194] ; [2019-BS-293] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000905814600001 |
| 出版者 | IOP Publishing Ltd |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Doctoral StartupFund of Liaoning Province |
| 源URL | [http://ir.imr.ac.cn/handle/321006/175719]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Erisen, Deniz Eren; Chen, Shanshan |
| 作者单位 | 1.Univ Sci & Technol China, Sch Mat Sci & Engn, Jinzhai Rd 96, CN-230026 Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shi changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 3.Univ Sci & Technol Liaoning, Sch Mat & Met, 189 Qianshan Middle Rd, Anshan 114051, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Erisen, Deniz Eren,Gu, Guisong,Chen, Shanshan,et al. Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation[J]. MATERIALS RESEARCH EXPRESS,2022,9(12):8. |
| APA | Erisen, Deniz Eren,Gu, Guisong,Chen, Shanshan,Yang, Ke,Zhang, Bingchun,&Shen, Minggang.(2022).Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation.MATERIALS RESEARCH EXPRESS,9(12),8. |
| MLA | Erisen, Deniz Eren,et al."Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation".MATERIALS RESEARCH EXPRESS 9.12(2022):8. |
入库方式： OAI收割
来源：金属研究所
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