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Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging
文献类型：期刊论文
| 作者 | Feng, B.1,2; Hong, R. Y.1,2,3; Wang, L. S.1,2; Guo, L.4; Li, H. Z.3; Ding, J.5; Zheng, Y.6; Wei, D. G.7 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 328期号:1-3页码:52-59 |
| 关键词 | Magnetite nanoparticle (MNPs) PEG diacid Magnetic fluids (MFs) Magnetic resonance imaging (MRI) |
| ISSN号 | 0927-7757 |
| 其他题名 | Colloid Surf. A-Physicochem. Eng. Asp. |
| 中文摘要 | The magnetite (Fe3O4) nanoparticles (MNPs) coated with PEG diacid via covalent bonds were prepared for magnetic resonance imaging (MRI). The surface of MNPs was first coated with (3-aminopropyl) tri-ethoxysilane (APITES) by a silanization reaction and then linked with PEG diacid via the reaction between -NH2 and -COOH to form well-dispersed surface functionalized biocompatible MNPs. The obtained nanoparticles were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) and thermogravimetry (TG). The MNPs had an average size of 20 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. In addition, PEG-6000 diacid coated Fe3O4 nanoparticles were used to perform the MRI experiments on the living rabbits with VX2 malignant tumor, the results showed that these nanoparticles appear to be a promising vehicle for MR imaging. (C) 2008 Elsevier B.V. All rights reserved. |
| 英文摘要 | The magnetite (Fe3O4) nanoparticles (MNPs) coated with PEG diacid via covalent bonds were prepared for magnetic resonance imaging (MRI). The surface of MNPs was first coated with (3-aminopropyl) tri-ethoxysilane (APITES) by a silanization reaction and then linked with PEG diacid via the reaction between -NH2 and -COOH to form well-dispersed surface functionalized biocompatible MNPs. The obtained nanoparticles were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) and thermogravimetry (TG). The MNPs had an average size of 20 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. In addition, PEG-6000 diacid coated Fe3O4 nanoparticles were used to perform the MRI experiments on the living rabbits with VX2 malignant tumor, the results showed that these nanoparticles appear to be a promising vehicle for MR imaging. (C) 2008 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | FE3O4 NANOPARTICLES ; CONTRAST AGENTS ; DRUG-DELIVERY ; RESONANCE ; NANOCRYSTALS ; HYPERTHERMIA ; GADOLINIUM ; GROWTH ; CANCER ; CELLS |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000260205000009 |
| 公开日期 | 2013-10-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/2748]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Soochow Univ, Dept Chem Engn, SIP, Suzhou 215123, Peoples R China 2.Soochow Univ, Key Lab Organ Synth Jiangsu Prov, SIP, Suzhou 215123, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase React, Beijing 100080, Peoples R China 4.Soochow Univ, Affiliated Hosp 1, MRI Div, Suzhou 215007, Peoples R China 5.IBM Corp, Rochester, MN 55901 USA 6.Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada 7.Harvard Univ, Sch Engn & Appl Sci, Ctr Nanoscale Syst, Cambridge, MA 02139 USA |
| 推荐引用方式 GB/T 7714 | Feng, B.,Hong, R. Y.,Wang, L. S.,et al. Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2008,328(1-3):52-59. |
| APA | Feng, B..,Hong, R. Y..,Wang, L. S..,Guo, L..,Li, H. Z..,...&Wei, D. G..(2008).Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,328(1-3),52-59. |
| MLA | Feng, B.,et al."Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 328.1-3(2008):52-59. |
入库方式： OAI收割
来源：过程工程研究所
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