In vivo study on heparin/poly-l-lysine-copper coating for surface functionalization of ureteral stent
文献类型：期刊论文
| 作者 | Awonusi, Bukola O.1,4; Li, Jianzhong3; Li, Hongwei3; Wang, Zhenyu3; Hu, Jiyuan2; Yang, Ke1; Zhao, Jing1 |
| 刊名 | REGENERATIVE BIOMATERIALS
 |
| 出版日期 | 2022-04-08 |
| 卷号 | 9页码:8 |
| 关键词 | ureteral stent heparin PLL-Cu nanoparticles in vivo implantation bacterial adhesion encrustation |
| ISSN号 | 2056-3418 |
| DOI | 10.1093/rb/rbac083 |
| 通讯作者 | Li, Jianzhong(174030098@qq.com) ; Yang, Ke(kyang@imr.ac.cn) ; Zhao, Jing(zhaojing@imr.ac.cn) |
| 英文摘要 | Polyurethane (PU) ureteral stents are used in clinics to maintain the ureteral patency. Due to biofilm formation and encrustation complications, long-term clinical usage has been limited. It is therefore necessary to develop an effective response to this unmet medical need. A heparin/poly-l-lysine/copper (NPs) coating was developed in our previous work that showed the effect of preventing infection and encrustation in vitro. In this work, a further study was conducted by grafting NPs on clinical ureteral stents that then were implanted into the infectious bladders of Wistar rats to investigate the effects of nanoparticles on bacterial growth and crystal deposition in vivo. It was found that decreased numbers of adherent microbes, urease amount splitting by bacteria, and deposited crystals were observed on the NPs stents with significant differences in comparison with PU stents. Besides, histological analysis showed that the NPs stents decreased the host tissue inflammation in close relation to the decrease biofilm formation and encrustation after 28 days of implantation. |
| 资助项目 | Liaoning Science and Technology Program[2020JH2/10300159] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000878297500003 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | Liaoning Science and Technology Program |
| 源URL | [http://ir.imr.ac.cn/handle/321006/176638]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Li, Jianzhong; Yang, Ke; Zhao, Jing |
| 作者单位 | 1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China 2.China Med Univ, Affiliated Hosp 1, Dept Urol, Shenyang 110001, Peoples R China 3.Gen Hosp Northern Theater Command, Dept Urol, Shenyang 110840, Peoples R China 4.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China |
| 推荐引用方式 GB/T 7714 | Awonusi, Bukola O.,Li, Jianzhong,Li, Hongwei,et al. In vivo study on heparin/poly-l-lysine-copper coating for surface functionalization of ureteral stent[J]. REGENERATIVE BIOMATERIALS,2022,9:8. |
| APA | Awonusi, Bukola O..,Li, Jianzhong.,Li, Hongwei.,Wang, Zhenyu.,Hu, Jiyuan.,...&Zhao, Jing.(2022).In vivo study on heparin/poly-l-lysine-copper coating for surface functionalization of ureteral stent.REGENERATIVE BIOMATERIALS,9,8. |
| MLA | Awonusi, Bukola O.,et al."In vivo study on heparin/poly-l-lysine-copper coating for surface functionalization of ureteral stent".REGENERATIVE BIOMATERIALS 9(2022):8. |
入库方式： OAI收割
来源：金属研究所
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