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High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application

文献类型：期刊论文

作者Chen, Shanshan1; Wang, Qingchuan1; Yang, Hui2; Yang, Ke1
刊名STEEL RESEARCH INTERNATIONAL
出版日期2022-11-28
页码11
ISSN号1611-3683
关键词biocompatibility bone implants coronary stents corrosion resistances high-nitrogen nickel-free stainless steels mechanical properties
DOI10.1002/srin.202200355
通讯作者Yang, Ke(kyang@imr.ac.cn)
英文摘要Metal materials such as stainless steel, cobalt-based alloy, and NiTi alloy used in clinic contain a certain amount of nickel (Ni) for the structure stability. Nickel ions can gradually dissolve into the human body even with much slow corrosion rate, causing allergic, inflammation, local tissue proliferation, and other adverse reactions to some people. To avoid these adverse effects of nickel, a new high-nitrogen nickel-free stainless steel (HNNFSS) using nitrogen and manganese instead of nickel to stabilize the austenite structure is developed, which exhibits much better mechanical properties, good corrosion resistance, and biocompatibility. Compared with the conventional orthopedic metal implants, the adhesion strength of HNNFSS implant with the surrounding tissue in animal is found to be stronger with new bone formation, promoted by both alkaline phosphatase (ALP) and osteocalcin (OCN) expressions. The vascular stent made of HNNFSS shows lower restenosis rate compared with the traditional 316L stainless steel stent, which is attributed to the promotion of endothelial cell and inhibition of smooth muscle cells, and superior blood compatibility. In conclusion, results from large number of studies show that high-nitrogen nickel-free stainless steel as a new kind of high-performance biomedical metallic material possesses great application potential.
资助项目Youth Innovation Promotion Association, Chinese Academy of Sciences ; [2019194]
WOS研究方向Metallurgy & Metallurgical Engineering
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000890423700001
资助机构Youth Innovation Promotion Association, Chinese Academy of Sciences
源URL[http://ir.imr.ac.cn/handle/321006/176985]  
专题金属研究所_中国科学院金属研究所
通讯作者Yang, Ke
作者单位1.Chinese Acad Sci, Inst Met Res, Shi changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Peoples R China
2.Zhongke Yian Med Technol Beijing Co Ltd, 2 Xiang St, Zone B, Airport Dev Tone, Beijing 101318, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Shanshan,Wang, Qingchuan,Yang, Hui,et al. High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application[J]. STEEL RESEARCH INTERNATIONAL,2022:11.
APA Chen, Shanshan,Wang, Qingchuan,Yang, Hui,&Yang, Ke.(2022).High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application.STEEL RESEARCH INTERNATIONAL,11.
MLA Chen, Shanshan,et al."High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application".STEEL RESEARCH INTERNATIONAL (2022):11.

入库方式： OAI收割

来源：金属研究所

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