Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier
文献类型：期刊论文
| 作者 | Shen, Zheyu1,2; Wei, Wei1,2; Zhao, Yonjiang1,2; Ma, Guanghui1; Dobashi, Toshiaki3; Maki, Yasuyuki3; Su, Zhiguo1; Wan, Jinpei1,2 |
| 刊名 | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
 |
| 出版日期 | 2008-11-15 |
| 卷号 | 35期号:4页码:271-282 |
| 关键词 | Poly(N-isopropylacrylamide-co-acrylamide-co-allylamine) Albumin nanospheres Adriamycin Thermal targeting Entrapment efficiency Controlled release |
| ISSN号 | 0928-0987 |
| 其他题名 | Eur. J. Pharm. Sci. |
| 中文摘要 | Thermosensitive Poly(N-isopropylacrylamide-co-acrylamide-co-allylamine) (PNIPAM-AAm-AA)-conjugated albumin nanospheres (PAN) was developed as a new thermal targeting anti-cancer drug carrier by conjugating PNIPAM-AAm-AA on the surface of albumin nanospheres (AN). AN with diameter below 200 nm and narrow size distribution was successfully prepared in the first step with desolvation technique. PNIPAM-AAm-AA with different molecular weight (M-w) was synthesized in the second step by radical polymerization and conjugated onto the surface of AN. Anti-cancer drug adriamycin (ADR) was then entrapped into the AN and PAN during the particle preparation. Compared with AN, the release rate of ADR from PAN in trypsin solution was slower, and decreased with increasing the conjugation amounts (hairy density) or M-w of PNIPAM-AAm-AA (hairy length). Moreover, the release of ADR from PAN above the cloud-point temperature (T-cp) of PNIPAM-AAm-AA became faster due to shrinkage of hairy thermosensitive polymer. To testify the thermal targetability in vivo, PAN was incubated with HepG2 cells. As expected, PAN can target cancer cells above the T-cp of PNIPAM-AAm-AA, whereas it cannot below the T-cp. These results might reflect that PAN may selectively accumulate onto solid tumors that are maintained above physiological temperature due to local hyperthermia. (C) 2008 Elsevier B.V. All rights reserved. |
| 英文摘要 | Thermosensitive Poly(N-isopropylacrylamide-co-acrylamide-co-allylamine) (PNIPAM-AAm-AA)-conjugated albumin nanospheres (PAN) was developed as a new thermal targeting anti-cancer drug carrier by conjugating PNIPAM-AAm-AA on the surface of albumin nanospheres (AN). AN with diameter below 200 nm and narrow size distribution was successfully prepared in the first step with desolvation technique. PNIPAM-AAm-AA with different molecular weight (M-w) was synthesized in the second step by radical polymerization and conjugated onto the surface of AN. Anti-cancer drug adriamycin (ADR) was then entrapped into the AN and PAN during the particle preparation. Compared with AN, the release rate of ADR from PAN in trypsin solution was slower, and decreased with increasing the conjugation amounts (hairy density) or M-w of PNIPAM-AAm-AA (hairy length). Moreover, the release of ADR from PAN above the cloud-point temperature (T-cp) of PNIPAM-AAm-AA became faster due to shrinkage of hairy thermosensitive polymer. To testify the thermal targetability in vivo, PAN was incubated with HepG2 cells. As expected, PAN can target cancer cells above the T-cp of PNIPAM-AAm-AA, whereas it cannot below the T-cp. These results might reflect that PAN may selectively accumulate onto solid tumors that are maintained above physiological temperature due to local hyperthermia. (C) 2008 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | AB BLOCK-COPOLYMER ; N-ISOPROPYLACRYLAMIDE ; MICELLES ; DELIVERY ; POLY(N-ISOPROPYLACRYLAMIDE) ; NANOPARTICLES ; HYPERTHERMIA ; ADRIAMYCIN ; PARTICLES ; DESIGN |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000260955400004 |
| 公开日期 | 2013-10-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/2841]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Coll Chem & Chem Engn, Beijing 100049, Peoples R China 3.Gunma Univ, Fac Engn, Dept Biol & Chem Engn, Gunma 3768515, Japan |
| 推荐引用方式 GB/T 7714 | Shen, Zheyu,Wei, Wei,Zhao, Yonjiang,et al. Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2008,35(4):271-282. |
| APA | Shen, Zheyu.,Wei, Wei.,Zhao, Yonjiang.,Ma, Guanghui.,Dobashi, Toshiaki.,...&Wan, Jinpei.(2008).Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,35(4),271-282. |
| MLA | Shen, Zheyu,et al."Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 35.4(2008):271-282. |
入库方式： OAI收割
来源：过程工程研究所
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