Preparation and characterization of thermo-responsive albumin nanospheres
文献类型：期刊论文
| 作者 | Shen, Zhe-Yu; Ma, Guang-Hui; Dobashi, Toshiaki; Maki, Yasuyuki; Su, Zhi-Guo |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2008-01-04 |
| 卷号 | 346期号:1-2页码:133-142 |
| 关键词 | poly(N-isopropylacrylamide-co-acrylamide)-block-polyallylamine albumin nanospheres rose bengal entrapment efficiency controlled release |
| ISSN号 | 0378-5173 |
| 其他题名 | Int. J. Pharm. |
| 中文摘要 | Thermo-responsive poly (N-isopropylacrylamide-co-acrylamide)-block-polyallylamine-conjugated albumin nanospheres (PAN), new thermal targeting anti-cancer drug carrier, was developed by conjugating poly (N-isopropylacrylamide-co-acrylamide)-block-polyallylamine (PNIPAM-AAm-b-PAA) on the surface of albumin nanospheres (AN). PAN may selectively accumulate onto solid tumors that are maintained above physiological temperature due to local hyperthermia. PNIPAM-AAm-b-PAA was synthesized by radical polymerization, and AN was prepared by ultrasonic emulsification. AN with diameter below 200 nm and narrow size distribution was obtained by optimizing the preparative conditions. Rose Bengal (RB) was used as model drug for entrapment into the AN and PAN during the particle preparation. The release rate of RB from PAN compared with AN in trypsin solution was slower, and decreased with the increase of PNIPAM-AAm-b-PAA molecular weight, which suggested that the existence of a steric hydrophilic barrier on AN made digestion of AN more difficult. Moreover, the release of RB from PAN above the cloud-point temperature (T-cp) of PNIPAM-AAm-b-PAA became faster. This was because the density of temperature-responsive polymers on AN was not so high, so that the interspace between the polymer chains increased after they shrunk due to the high temperature. As a result, the biodegradable AN was attacked more easily by trypsin. The design of PAN overcame the disadvantages of temperature-responsive polymeric micelles. (C) 2007 Elsevier B.V. All rights reserved. |
| 英文摘要 | Thermo-responsive poly (N-isopropylacrylamide-co-acrylamide)-block-polyallylamine-conjugated albumin nanospheres (PAN), new thermal targeting anti-cancer drug carrier, was developed by conjugating poly (N-isopropylacrylamide-co-acrylamide)-block-polyallylamine (PNIPAM-AAm-b-PAA) on the surface of albumin nanospheres (AN). PAN may selectively accumulate onto solid tumors that are maintained above physiological temperature due to local hyperthermia. PNIPAM-AAm-b-PAA was synthesized by radical polymerization, and AN was prepared by ultrasonic emulsification. AN with diameter below 200 nm and narrow size distribution was obtained by optimizing the preparative conditions. Rose Bengal (RB) was used as model drug for entrapment into the AN and PAN during the particle preparation. The release rate of RB from PAN compared with AN in trypsin solution was slower, and decreased with the increase of PNIPAM-AAm-b-PAA molecular weight, which suggested that the existence of a steric hydrophilic barrier on AN made digestion of AN more difficult. Moreover, the release of RB from PAN above the cloud-point temperature (T-cp) of PNIPAM-AAm-b-PAA became faster. This was because the density of temperature-responsive polymers on AN was not so high, so that the interspace between the polymer chains increased after they shrunk due to the high temperature. As a result, the biodegradable AN was attacked more easily by trypsin. The design of PAN overcame the disadvantages of temperature-responsive polymeric micelles. (C) 2007 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | AB BLOCK-COPOLYMER ; POLYMERIC MICELLES ; PHASE-BEHAVIOR ; DRUG-DELIVERY ; NANOPARTICLES ; ADRIAMYCIN ; PARTICLES ; SERUM ; ACID) |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000251809100016 |
| 公开日期 | 2013-10-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/2842]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Zhe-Yu,Ma, Guang-Hui,Dobashi, Toshiaki,et al. Preparation and characterization of thermo-responsive albumin nanospheres[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,346(1-2):133-142. |
| APA | Shen, Zhe-Yu,Ma, Guang-Hui,Dobashi, Toshiaki,Maki, Yasuyuki,&Su, Zhi-Guo.(2008).Preparation and characterization of thermo-responsive albumin nanospheres.INTERNATIONAL JOURNAL OF PHARMACEUTICS,346(1-2),133-142. |
| MLA | Shen, Zhe-Yu,et al."Preparation and characterization of thermo-responsive albumin nanospheres".INTERNATIONAL JOURNAL OF PHARMACEUTICS 346.1-2(2008):133-142. |
入库方式： OAI收割
来源：过程工程研究所
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