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Intercellular genetic tracing of cardiac endothelium in the developing heart

文献类型：期刊论文

作者Liu, Kuo2,3; Jin, Hengwei3; Zhang, Shaohua3; Tang, Muxue3; Meng, Xinfeng1,3; Li, Yan4,5; Pu, Wenjuan3; Lui, Kathy O.6; Zhou, Bin1,2,3
刊名DEVELOPMENTAL CELL
出版日期2023-08-21
卷号58期号:16页码:1502-+
ISSN号1534-5807
DOI10.1016/j.devcel.2023.05.021
通讯作者Liu, Kuo(liukuo2015@sibcb.ac.cn) ; Zhou, Bin(zhoubin@sibs.ac.cn)
英文摘要Cardiac resident macrophages play vital roles in heart development, homeostasis, repair, and regeneration. Recent studies documented the hematopoietic potential of cardiac endothelium that supports the generation of cardiac macrophages and peripheral blood cells in mice. However, the conclusion was not strongly sup-ported by previous genetic tracing studies, given the non-specific nature of conventional Cre-loxP tracing tools. Here, we develop an intercellular genetic labeling system that can permanently trace heart-specific endothelial cells based on cell-cell interaction in mice. Results from cell-cell contact-mediated genetic fate mapping demonstrate that cardiac endothelial cells do not exhibit hemogenic potential and do not contribute to cardiac macrophages or other circulating blood cells. This Matters Arising paper is in response to Shigeta et al. (2019), published in Developmental Cell. See also the response by Liu and Nakano (2023), published in this issue.
WOS关键词MACROPHAGES ; LINEAGE ; ORIGIN ; REVEALS ; FORM
资助项目National Natural Science Foundation of China[32050087] ; National Natural Science Foundation of China[32100648] ; National Natural Science Foundation of China[32200661] ; National Natural Science Foundation of China[2019YFA0110403] ; National Key Research amp; Development Program of China[2022YFA1104200] ; National Key Research amp; Development Program of China[2019YFA0802000] ; National Key Research amp; Development Program of China[2022ZZ01015] ; Research Funds of Hangzhou Institute for Advanced Study[YSBR-012] ; CAS Project for Young Scientists in Basic Research[JCYJ-SHFY-2021-0] ; Shanghai Pilot Program for Basic Research, CAS, Shanghai Branch[2017ZT07S347] ; Pearl River Talent Recruitment Program of Guagdong Province ; Shanghai Municipal Science and Technology Major Project (Genome Tagging Project), New Cornerstone Science Foundation through the New Cornerstone Investigator Program ; XPLORER PRIZE ; [82088101]
WOS研究方向Cell Biology ; Developmental Biology
语种英语
WOS记录号WOS:001062984800001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/306140]  
专题新药研究国家重点实验室
通讯作者Liu, Kuo; Zhou, Bin
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
2.Univ Chinese Acad Sci, Sch Life Sci, Hangzhou Inst Adv Study, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China
3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,New Cornerstone Sc, Shanghai 200031, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
6.Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Dept Chem Pathol, Hong Kong 999077, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Kuo,Jin, Hengwei,Zhang, Shaohua,et al. Intercellular genetic tracing of cardiac endothelium in the developing heart[J]. DEVELOPMENTAL CELL,2023,58(16):1502-+.
APA Liu, Kuo.,Jin, Hengwei.,Zhang, Shaohua.,Tang, Muxue.,Meng, Xinfeng.,...&Zhou, Bin.(2023).Intercellular genetic tracing of cardiac endothelium in the developing heart.DEVELOPMENTAL CELL,58(16),1502-+.
MLA Liu, Kuo,et al."Intercellular genetic tracing of cardiac endothelium in the developing heart".DEVELOPMENTAL CELL 58.16(2023):1502-+.

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来源：上海药物研究所

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