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  2. 上海药物研究所
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Five undescribed abietane-type diterpenes of Callicarpa macrophylla

文献类型：期刊论文

作者Du, Gao-Xiang2,3; Chen, Tong2,3; Wang, Ge3,4; Liu, Ying-Bo1; Zheng, Liu3,4; Li, Chen-Yue3,4; Wang, Wen-Qiong3,5; Xuan, Li-Jiang2,3,4,5
刊名FITOTERAPIA
出版日期2023-10-01
卷号170页码:10
ISSN号0367-326X
关键词Callicarpa macrophylla Verbenaceae Abietane-type diterpenoids PCSK9 Macrophypene F -J
DOI10.1016/j.fitote.2023.105629
通讯作者Wang, Wen-Qiong(wenqiong1019@126.com) ; Xuan, Li-Jiang(ljxuan@simm.ac.cn)
英文摘要A phytochemical investigation of the medicinal plant Callicarpa macrophylla resulted in the characterization of two rare rearrangement abietane-type diterpenoids, macrophypene F-G (1-2), and three abietane diterpenoids, named macrophypene H-J (3-5). Additionally, five known diterpenoids (6-10) were identified. The structures of the newly discovered compounds were fully established through extensive analysis of HRESIMS, 1D and 2D NMR data. The absolute configurations of the isolated compounds were determined using CD comparison, chemical methods, and X-ray crystal diffraction experiments. Subsequently, all isolated diterpenoids were evaluated for their inhibitory effects on extracellular PCSK9 protein levels by PCSK9 AlphaLISA screening. Jiadfenoic acid B (6, 56.80% inhibition at 20 & mu;M) and holophyllin F (10, 43.18% inhibition at 20 & mu;M) significantly decreased PCSK9 protein levels in medium of HepG2 cells.
WOS关键词ROOTS
资助项目Shanghai Municipal Science and Technology Major Project[TM202301L001]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:001061667400001
源URL[http://119.78.100.183/handle/2S10ELR8/306170]  
专题新药研究国家重点实验室
通讯作者Wang, Wen-Qiong; Xuan, Li-Jiang
作者单位1.Zunyi Med & Pharmaceut Coll, Zunyi 563006, Guizhou, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Du, Gao-Xiang,Chen, Tong,Wang, Ge,et al. Five undescribed abietane-type diterpenes of Callicarpa macrophylla[J]. FITOTERAPIA,2023,170:10.
APA Du, Gao-Xiang.,Chen, Tong.,Wang, Ge.,Liu, Ying-Bo.,Zheng, Liu.,...&Xuan, Li-Jiang.(2023).Five undescribed abietane-type diterpenes of Callicarpa macrophylla.FITOTERAPIA,170,10.
MLA Du, Gao-Xiang,et al."Five undescribed abietane-type diterpenes of Callicarpa macrophylla".FITOTERAPIA 170(2023):10.

入库方式： OAI收割

来源：上海药物研究所

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