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Cell membrane-coated mesoporous silica nanorods overcome sequential drug delivery barriers against colorectal cancer

文献类型：期刊论文

作者Wang, Jie2,3,4; Pan, Hao5; Li, Jingyi2; Nie, Di2,6; Zhuo, Yan2; Lv, Yishan2,3; Wang, Ning2,6; Chen, Hao1,6; Guo, Shiyan2,6; Gan, Yong2,6
刊名CHINESE CHEMICAL LETTERS
出版日期2023-06-01
卷号34期号:6页码:6
ISSN号1001-8417
关键词Cell membrane coating Rod shape Sequential delivery Nuclear accumulation Colorectal cancer
DOI10.1016/j.cclet.2022.107828
通讯作者Yang, Xinggang(yangxg123@163.com) ; Yu, Miaorong(mryu@simm.ac.cn)
英文摘要Local delivery of nanomedicines holds therapeutic promise for colorectal cancer (CRC). However, it presents tremendous challenges due to the existence of multiple physiological barriers, especially intra-cellular obstacles, including intracellular trafficking, subcellular accumulation, and drug release. Herein, we report a multifunctional nanoparticle (CMSNR) by wrapping the mesoporous silica nanorod with cell membrane derived from CRC cells for improved chemotherapy. Compared with their naked counterparts, the cell membrane endowed CMSNR with homotypic targeting and improved cellular uptake capacities. Due to the rod-like shape, CMSNR achieved superior colorectal mucus permeability, enhanced tumor ac-cumulation, and boosted cellular uptake than their spherical counterparts. Moreover, the internalized CM-SNR underwent robust intracellular trafficking and gained augmented motility toward the nucleus, lead-ing to efficient perinuclear accumulation and a subsequent 5.6-fold higher nuclear accumulation of loaded drug than that of nanospheres. In the orthotopic colorectal tumor-bearing nude mice, rectally admin-istrated mefuparib hydrochloride (MPH)-loaded CMSNR traversed the colorectal mucus, penetrated the tumor tissue, and successfully aggregated in the perinuclear region of cancer cells, thus exhibiting signif-icantly improved antitumor outcomes. Our findings highlight the shape-based design of cell membrane-coated nanoparticles that can address sequential drug delivery barriers has a promising future in cancer nanomedicine. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
WOS关键词NANOPARTICLE ; SHAPE ; DESIGN ; CHEMOTHERAPY ; PEGYLATION
资助项目National Natural Science Foundation of China[82073773] ; National Natural Science Foundation of China[82104078] ; Major International Joint Research Project of Chinese Academy of Sciences[153631KYSB20190020]
WOS研究方向Chemistry
语种英语
出版者ELSEVIER SCIENCE INC
WOS记录号WOS:000982041900001
源URL[http://119.78.100.183/handle/2S10ELR8/306173]  
专题新药研究国家重点实验室
通讯作者Yang, Xinggang; Yu, Miaorong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
5.Liaoning Univ, Coll Pharm, Shenyang 110036, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jie,Pan, Hao,Li, Jingyi,et al. Cell membrane-coated mesoporous silica nanorods overcome sequential drug delivery barriers against colorectal cancer[J]. CHINESE CHEMICAL LETTERS,2023,34(6):6.
APA Wang, Jie.,Pan, Hao.,Li, Jingyi.,Nie, Di.,Zhuo, Yan.,...&Yu, Miaorong.(2023).Cell membrane-coated mesoporous silica nanorods overcome sequential drug delivery barriers against colorectal cancer.CHINESE CHEMICAL LETTERS,34(6),6.
MLA Wang, Jie,et al."Cell membrane-coated mesoporous silica nanorods overcome sequential drug delivery barriers against colorectal cancer".CHINESE CHEMICAL LETTERS 34.6(2023):6.

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来源：上海药物研究所

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