Oxygenated Cembrane Diterpenes from the South China Sea Soft Coral Sinularia tumulosa
文献类型：期刊论文
| 作者 | Zhu, Sheng-Hui2,3,4; Yu, Dan-Dan6; Su, Ming-Zhi6; Luo, Hui1; Yao, Li-Gong4; Gu, Feifei7; Liang, Lin-Fu5; Wang, Hong2,3; Guo, Yue-Wei2,3,4,6,8
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2023-06-09 |
| 页码 | 5 |
| ISSN号 | 1612-1872 |
| 关键词 | antibacterial activity cembrane diterpene Sinularia tumulosa soft coral structural elucidation |
| DOI | 10.1002/cbdv.202300589 |
| 通讯作者 | Liang, Lin-Fu(lianglinfu@csuft.edu.cn) ; Wang, Hong(hongw@zjut.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | The chemical investigation of the rarely studied soft coral Sinularia tumulosa resulted in the discovery of five oxygenated cembrane diterpenes 1-5, including two new compounds situmulins A (1) and B (2). The structures of 1 and 2 were established through the extensive analyses of 1D and 2D NMR spectral data together with the comparisons with the known compounds. Furthermore, the absolute configuration of 1 was determined by the time-dependent density functional theory (TDDFT) ECD approach, while the relative configuration of 2 was assigned via the quantum mechanical-NMR (QM-NMR) calculations. It might be worth to point out it is the first time to disclose the presence of cembrane diterpenes in the title species. In the bioassays, compound 2 not only showed strong antibacterial activities against fish pathogenic bacteria Streptococcus parauberis FP KSP28 and Phoyobacterium damselae FP2244 with both minimum inhibitory concentration for 90 % (MIC90) values of 25 mu M, but also demonstrated substantial inhibitory efficacy against vancomycin-resistant Enterococcus faecium bacteria G1, G4, G7, G8 and G13 from several individuals, with MIC90 values of 25, 50, 100, 50 and 25 mu M, respectively. |
| WOS关键词 | SECONDARY METABOLITES |
| 资助项目 | National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[41876194] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:001003386900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306182]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liang, Lin-Fu; Wang, Hong; Guo, Yue-Wei |
| 作者单位 | 1.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang Res & Dev Marine Microbial Resou, Zhanjiang 524023, Peoples R China 2.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 5.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China 6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 7.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China 8.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Sheng-Hui,Yu, Dan-Dan,Su, Ming-Zhi,et al. Oxygenated Cembrane Diterpenes from the South China Sea Soft Coral Sinularia tumulosa[J]. CHEMISTRY & BIODIVERSITY,2023:5. |
| APA | Zhu, Sheng-Hui.,Yu, Dan-Dan.,Su, Ming-Zhi.,Luo, Hui.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2023).Oxygenated Cembrane Diterpenes from the South China Sea Soft Coral Sinularia tumulosa.CHEMISTRY & BIODIVERSITY,5. |
| MLA | Zhu, Sheng-Hui,et al."Oxygenated Cembrane Diterpenes from the South China Sea Soft Coral Sinularia tumulosa".CHEMISTRY & BIODIVERSITY (2023):5. |
入库方式： OAI收割
来源：上海药物研究所
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