Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging
文献类型：期刊论文
| 作者 | Wei, Ruwei2; Dong, Yan2; Wang, Xueli3; Li, Jin2; Lei, Zuhai4; Hu, Zhubin3; Chen, Jinquan3; Sun, Haitao3; Chen, Hao5; Luo, Xiao1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2023-05-22 |
| 卷号 | 145期号:22页码:12013-12022 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/jacs.3c00594 |
| 通讯作者 | Yang, Youjun(youjunyang@ecust.edu.cn) |
| 英文摘要 | The shortwave infrared (SWIR) spectral region beyond1200 nm offersoptimal tissue penetration depth and has broad potential in diagnosis,therapy, and surgery. Here, we devised a novel class of fluorochromicscaffold, i.e., a tetra-benzannulated xanthenoid (EC7). EC7 absorbs/emits maximally at 1204/1290 nm in CH2Cl2 and exhibits an unparalleled molar absorptivityof 3.91 x 10(5) cm(-1) M-1 and high transparency to light at 400-900 nm. It also exhibitedhigh resistance toward both photobleaching and symmetry breaking dueto its unique structural rigidity. It is feasible for in vivo bioimagingand particularly suitable to couple with the shorter-wavelength analoguesfor high-contrast multiplexing. High-contrast dual-channel intraoperativeimaging of the hepatobiliary system and three-channel in vivo imagingof the intestine, the stomach, and the vasculature were showcased. EC7 is a benchmark fluorochrome for facile biomedical exploitationof the SWIR region beyond 1200 nm. |
| WOS关键词 | HEPTAMETHINE CYANINE DYES ; BILE-DUCT INJURY ; INDOCYANINE-GREEN ; LAPAROSCOPIC CHOLECYSTECTOMY ; ORGANIC FLUOROPHORES ; SYMMETRY-BREAKING ; BRIGHT ; RHODAMINE ; WAVELENGTH ; DESIGN |
| 资助项目 | National Key Research and Development Program of China[2022YFD17800] ; National Natural Science Foundation of China[21908065] ; National Natural Science Foundation of China[22078098] ; National Natural Science Foundation of China[22278138] ; National Natural Science Foundation of China[92156024] ; National Natural Science Foundation of China[91850202] ; National Natural Science Foundation of China[12274128] ; Shanghai Rising-Star Program[21QA1402600] ; Shanghai Academic/Technology Research Leader[22XD1421000] ; Fundamental Research Funds for the Central Universities ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering ; Research Funds of Happiness Flower ECNU[2020JK2103] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001005908700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306188]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Youjun |
| 作者单位 | 1.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev, Sch Chem & Mol Engn, Dongchuan Rd 500, Shanghai 200241, Peoples R China 2.East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China 3.East China Normal Univ, Sch Phys & Elect Sci, State Key Lab Precis Spect, Dongchuan Rd 500, Shanghai 200241, Peoples R China 4.Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Zhangheng Rd 826, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Ruwei,Dong, Yan,Wang, Xueli,et al. Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2023,145(22):12013-12022. |
| APA | Wei, Ruwei.,Dong, Yan.,Wang, Xueli.,Li, Jin.,Lei, Zuhai.,...&Yang, Youjun.(2023).Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,145(22),12013-12022. |
| MLA | Wei, Ruwei,et al."Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 145.22(2023):12013-12022. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。