LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1
文献类型：期刊论文
| 作者 | Meng, Jiao2; Lv, Zhenyu2,4; Chen, Xia3; Sun, Chuanxin2; Jin, Can3; Ding, Kan3,4,5 ; Chen, Chang1,2,4
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| 刊名 | ISCIENCE
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| 出版日期 | 2023-05-19 |
| 卷号 | 26期号:5页码:22 |
| DOI | 10.1016/j.isci.2023.106573 |
| 通讯作者 | Ding, Kan(dingkan@simm.ac.cn) ; Chen, Chang(changchen@moon.ibp.ac.cn) |
| 英文摘要 | Muscle stem cells, called satellite cells (SCs), are employed to repair and rebuild muscle. SC-based therapeutic strategies are urgently needed. In this study, we showed that Lycium barbarum extract (LBE) improved the number of SCs and enhanced muscle regeneration by promoting SC activation and self-renewal in both adult and aging mice. L. barbarum polysaccharide (LBP), the main component of LBE, also played a similar role. More importantly, LBP1C-2, a homo-geneous polysaccharide isolated from LBP, was uncovered to be an active compo-nent in regulating SC function. Mechanism study revealed that LBP1C-2 might bind to FGFR1 to activate SCs and promote SC self-renewal through Spry1 upregula-tion. This might be the first study to show that LBE participated in the regulation of SCs, and the active components and targets of LBE were identified. This study lays a theoretical foundation for the medicinal or auxiliary medicinal use of L. bar-barum in skeletal muscle. |
| WOS关键词 | STEM-CELL ; SELF-RENEWAL ; GROWTH ; REGENERATION ; QUIESCENCE ; ACTIVATION ; MECHANISM ; STRENGTH ; SPROUTY1 ; FAILURE |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB39000000] ; National Key R&D Program of China[2022YFA1303000] ; National Key R&D Program of China[2022YFA1305100] ; Ningxia Key Research and Development Program Grant[2016BZ05] ; regional key projects of science and technology service network plan (STS plan) of Chinese Academy of Sciences[KFJ-STS-QYZD-181] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:001001084400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306197]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Kan; Chen, Chang |
| 作者单位 | 1.Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China 2.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Jiao,Lv, Zhenyu,Chen, Xia,et al. LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1[J]. ISCIENCE,2023,26(5):22. |
| APA | Meng, Jiao.,Lv, Zhenyu.,Chen, Xia.,Sun, Chuanxin.,Jin, Can.,...&Chen, Chang.(2023).LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1.ISCIENCE,26(5),22. |
| MLA | Meng, Jiao,et al."LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1".ISCIENCE 26.5(2023):22. |
入库方式： OAI收割
来源：上海药物研究所
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