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Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease

文献类型：期刊论文

作者Jing, Shisuo2,3; Chen, Huayuan3,4; Liu, Ergang3; Zhang, Meng5; Shen, Huan3,7; Zeng, Feng6; Fang, Yuefei3; Muhitdinov, Bahtiyor1,7; Huang, Yongzhuo2,3,7
刊名CARBOHYDRATE POLYMERS
出版日期2023-09-15
卷号316页码:15
ISSN号0144-8617
关键词Inflammatory bowel disease Quercetin colon-targeted delivery Pectin microsphere Oligochitosan Immune microenvironment
DOI10.1016/j.carbpol.2023.121025
通讯作者Liu, Ergang(liuergang@zidd.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要Inflammatory bowel disease (IBD) is a chronic, life quality-reducing disease with no cures available yet. To develop an effective medication suitable for long-term use is an urgent but unmet need. Quercetin (QT) is a natural dietary flavonoid with good safety and multifaceted pharmacological activities against inflammation. However, orally administrated quercetin yields unproductive outcomes for IBD treatment because of its poor solubility and extensive metabolism in the gastrointestinal tract. In this work, a colon-targeted QT delivery system (termed COS-CaP-QT) was developed, of which the pectin (PEC)/Ca2+ microspheres were prepared and then crosslinked by oligochitosan (COS). The drug release profile of COS-CaP-QT was pH-dependent and colon microenvironment-responsive, and COS-CaP-QT showed preferential distribution in the colon. The mechanism study showed that QT triggered the Notch pathway to regulate the proliferation of T helper 2 (Th2) cells and group 3 innate lymphoid cells (ILC3s) and the inflammatory microenvironment was remodeled. The in vivo therapeutic results revealed that COS-CaP-QT could relieve the colitis symptoms and maintain the colon length and intestinal barrier integrity.
WOS关键词SWELLING BEHAVIOR ; DELIVERY-SYSTEMS ; DRUG-DELIVERY ; RAT INTESTINE ; NOTCH ; PECTIN ; CHITOSAN ; CELLS ; PHARMACOKINETICS ; POLYSACCHARIDES
资助项目National Key Research and Development Program of China[2021YFE0103100] ; National Key Research and Development Program of China[2021YFC2400600] ; National Natural Science Foundation of China[81925035] ; National Natural Science Foundation of China[201101172] ; National Natural Science Foundation of China[31901002] ; Public Welfare Scientific Research Project of Futian District of Shenzhen[FTWS2022064] ; Public Welfare Scientific Research Project of Futian District of Shenzhen[FTWS2020050] ; Department of Science and Technology of Guangdong Province (High-level new RD institute)[2019B090904008] ; High-level Innovative Research Institute[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011]
WOS研究方向Chemistry ; Polymer Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:001010752400001
源URL[http://119.78.100.183/handle/2S10ELR8/306203]  
专题中国科学院上海药物研究所
通讯作者Liu, Ergang; Huang, Yongzhuo
作者单位1.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan
2.Zunyi Med Univ, Sch Pharm, Zunyi 563006, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
4.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
5.Zhejiang Univ, Womens Hosp, Dept Pharm, Sch Med, Hangzhou 310006, Peoples R China
6.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou 510450, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Jing, Shisuo,Chen, Huayuan,Liu, Ergang,et al. Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease[J]. CARBOHYDRATE POLYMERS,2023,316:15.
APA Jing, Shisuo.,Chen, Huayuan.,Liu, Ergang.,Zhang, Meng.,Shen, Huan.,...&Huang, Yongzhuo.(2023).Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease.CARBOHYDRATE POLYMERS,316,15.
MLA Jing, Shisuo,et al."Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease".CARBOHYDRATE POLYMERS 316(2023):15.

入库方式： OAI收割

来源：上海药物研究所

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