Comparative Characterization of the Ginsenosides from Six Panax Herbal Extracts and Their In Vitro Rat Gut Microbial Metabolites by Advanced Liquid Chromatography-Mass Spectrometry Approaches
文献类型：期刊论文
| 作者 | Mi, Yue-Guang2,3; Xu, Xiao-Yan2,3; Hong, Li-Li2,3; Jiang, Mei-Ting2,3; Chen, Bo-Xue2,3; Li, Xiao-Hang2,3; Wang, Hong-Da2,3; Zou, Ya-Dan2,3; Zhao, Xin2,3; Li, Zheng1,2,3 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2023-06-09 |
| 卷号 | 71期号:24页码:9391-9403 |
| ISSN号 | 0021-8561 |
| 关键词 | Panax multicomponent characterization quantitative assay gut microbiota in vitro biotransformation liquid chromatography-massspectrometry |
| DOI | 10.1021/acs.jafc.3c01093 |
| 通讯作者 | Guo, De-An(daguo@simm.ac.cn) ; Yang, Wen-Zhi(wzyang0504@tjutcm.edu.cn) |
| 英文摘要 | Ginsengextracts are extensively used as raw materials for foodsupplements and herbal medicines. This study aimed to characterizeginsenosides obtained from six Panax plant extracts(Panax ginseng, red ginseng, Panax quinquefolius, Panax notoginseng, Panax japonicus, and Panax japonicus var. major) andcompared them with their in vitro metabolic profilesmediated by rat intestinal microbiota. Ultrahigh-performance liquidchromatography/ion mobility-quadrupole time-of-flight massspectrometry (UHPLC/IM-QTOF-MS) with scheduled multiple reaction monitoring(sMRM) quantitation methods were developed to characterize and comparethe ginsenoside composition of the different extracts. After in vitro incubation, 248 ginsenosides/metabolites were identifiedby UHPLC/IM-QTOF-MS in six biotransformed samples. Deglycosylationwas determined to be the main metabolic pathway of ginsenosides, andprotopanaxadiol-type and oleanolic acid-type saponins were easierto be easily metabolized. Compared with the ginsenosides in plantextracts, those remaining in six biotransformed samples were considerablyfewer after biotransformation for 8 h. However, the compositionaldifferences in four subtypes of the ginsenosides among the six Panax plants became more distinct. |
| WOS关键词 | HUMAN INTESTINAL MICROFLORA ; PRECURSOR IONS LIST ; FLOWER BUDS ; IDENTIFICATION ; SAPONINS ; GINSENG ; BIOTRANSFORMATION ; PROFILE |
| 资助项目 | Tianjin Committee of Science and Technology of China[22ZYJDSS00040] ; National Natural Science Foundation of China[81872996] ; National Admin-istration of Traditional Chinese Medicine[ZYYCXTD-D-202002] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001006279500001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306212]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-An; Yang, Wen-Zhi |
| 作者单位 | 1.Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin 301617, Peoples R China 2.Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China 4.Shanghai Inst Mat Med, Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mi, Yue-Guang,Xu, Xiao-Yan,Hong, Li-Li,et al. Comparative Characterization of the Ginsenosides from Six Panax Herbal Extracts and Their In Vitro Rat Gut Microbial Metabolites by Advanced Liquid Chromatography-Mass Spectrometry Approaches[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(24):9391-9403. |
| APA | Mi, Yue-Guang.,Xu, Xiao-Yan.,Hong, Li-Li.,Jiang, Mei-Ting.,Chen, Bo-Xue.,...&Yang, Wen-Zhi.(2023).Comparative Characterization of the Ginsenosides from Six Panax Herbal Extracts and Their In Vitro Rat Gut Microbial Metabolites by Advanced Liquid Chromatography-Mass Spectrometry Approaches.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(24),9391-9403. |
| MLA | Mi, Yue-Guang,et al."Comparative Characterization of the Ginsenosides from Six Panax Herbal Extracts and Their In Vitro Rat Gut Microbial Metabolites by Advanced Liquid Chromatography-Mass Spectrometry Approaches".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.24(2023):9391-9403. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。