Hypsochromic Shift Donor-Acceptor NIR-II Dye for High-Efficiency Tumor Imaging
文献类型：期刊论文
| 作者 | Li, Jiafeng1,2; Ji, Aiyan2; Lei, Meiling2,3; Xuan, Liwen2,3; Song, Ruihu2; Feng, Xin4; Lin, Haixia1; Chen, Hao2,3 |
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2023-06-09 |
| 页码 | 14 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.3c00253 |
| 通讯作者 | Feng, Xin(feng_xin@jlu.edu.cn) ; Lin, Haixia(haixialin@staff.shu.edu.cn) ; Chen, Hao(haoc@simm.ac.cn) |
| 英文摘要 | Nowadays, second near-infrared window (NIR-II) dyes'developmentfocuses on pursuing a longer absorption/emission wavelength and higherquantum yield, which usually means an extended pi conjugationsystem, resulting in an enormous molecular weight and poor druggability.Most researchers thought that the reduced pi conjugation systemwould bring on a blueshift spectrum that causes dim imaging qualities.Little efforts have been made to study smaller NIR-II dyes with areduced pi conjugation system. Herein, we synthesized a reduced pi conjugation system donor-acceptor (D-A) probe TQ-1006(Em = 1006 nm). Compared with its counterpart donor-acceptor-donor(D-A-D) structure TQT-1048 (Em = 1048 nm), TQ-1006 exhibited comparableexcellent blood vessels, lymphatic drainage imaging performance, anda higher tumor-to-normal tissue (T/N) ratio. An RGD conjugated probeTQ-RGD showed an extra high contrast tumor imaging (T/N >= 10),further proving D-A dyes' excellent NIR-II biomedical imagingapplications. Overall, the D-A framework provides a promising approachto designing next-generation NIR-II fluorophores. |
| WOS关键词 | PHOTOTHERMAL THERAPY ; RATIONAL DESIGN ; CHEMICAL SPACE ; FLUOROPHORES ; SURGERY ; RGD |
| 资助项目 | National Science and Technology Innovation 2030 Major Project of China[2021ZD0203900] ; Lingang Laboratory[LG-QS-202206-01] ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China[82071976] ; Shanghai Pujiang Program[19PJ1411100] ; Nantong Basic Science Research Program[JC2021014] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001006264100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306218]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Feng, Xin; Lin, Haixia; Chen, Hao |
| 作者单位 | 1.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Jilin Univ, Coll Vet Med, Changchun 130062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiafeng,Ji, Aiyan,Lei, Meiling,et al. Hypsochromic Shift Donor-Acceptor NIR-II Dye for High-Efficiency Tumor Imaging[J]. JOURNAL OF MEDICINAL CHEMISTRY,2023:14. |
| APA | Li, Jiafeng.,Ji, Aiyan.,Lei, Meiling.,Xuan, Liwen.,Song, Ruihu.,...&Chen, Hao.(2023).Hypsochromic Shift Donor-Acceptor NIR-II Dye for High-Efficiency Tumor Imaging.JOURNAL OF MEDICINAL CHEMISTRY,14. |
| MLA | Li, Jiafeng,et al."Hypsochromic Shift Donor-Acceptor NIR-II Dye for High-Efficiency Tumor Imaging".JOURNAL OF MEDICINAL CHEMISTRY (2023):14. |
入库方式： OAI收割
来源：上海药物研究所
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