Five undescribed guanidine alkaloids from Plumbago zeylanica
文献类型：期刊论文
| 作者 | Zheng, Liu1,2; Guo, Peng-Ju2,3; Zhu, Yao1,2; Li, Chen-Yue1,2; Wang, Wen-Qiong2; Xuan, Li-Jiang1,2
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2023-07-01 |
| 卷号 | 168页码:5 |
| 关键词 | Plumbago zeylanica Plumbaginaceae Guanidine alkaloids |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2023.105538 |
| 通讯作者 | Wang, Wen-Qiong(wenqiong1019@126.com) ; Xuan, Li-Jiang(ljxuan@simm.ac.cn) |
| 英文摘要 | Five undescribed guanidine alkaloids, plumbagines H-K (1-4) and plumbagoside E (5), as well as five known analogues (6-10) were isolated from the roots of Plumbago zeylanica. Their structures were established by extensive spectroscopic analyses and chemical methods. In addition, 1-10 were accessed their anti-inflammatory activities by measuring nitric oxide (NO) concentrations in LPS-induced RAW 264.7 cells. However, all com-pounds especially 1 and 3-5 could not inhibit the secretion of NO but significant increase the secretion of NO. The result reminded us that 1-10 may become potential novel immune potentiators. |
| WOS关键词 | ROOT |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; Shanghai Municipal Science and Technology Major Project[TM202301L001] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001010388600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306224]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wen-Qiong; Xuan, Li-Jiang |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Liu,Guo, Peng-Ju,Zhu, Yao,et al. Five undescribed guanidine alkaloids from Plumbago zeylanica[J]. FITOTERAPIA,2023,168:5. |
| APA | Zheng, Liu,Guo, Peng-Ju,Zhu, Yao,Li, Chen-Yue,Wang, Wen-Qiong,&Xuan, Li-Jiang.(2023).Five undescribed guanidine alkaloids from Plumbago zeylanica.FITOTERAPIA,168,5. |
| MLA | Zheng, Liu,et al."Five undescribed guanidine alkaloids from Plumbago zeylanica".FITOTERAPIA 168(2023):5. |
入库方式： OAI收割
来源：上海药物研究所
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