Recent Advances in Pro-PROTAC Development to Address On-Target Off-Tumor Toxicity
文献类型：期刊论文
| 作者 | Chen, Chuanjie1,2; Yang, Yiwen3; Wang, Zhe3; Li, Huiwen1,2; Dong, Chanjuan2; Zhang, Xuan1,2,3
|
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2023-06-15 |
| 页码 | 13 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.3c00302 |
| 通讯作者 | Zhang, Xuan(zhangxuan@simm.ac.cn) |
| 英文摘要 | Proteolysis-targetingchimera (PROTAC) technology represents anovel and promising modality for targeted protein degradation withtransformative implications for the clinical management of variousdiseases. Despite notable advantages, the possibility of on-targetoff-tumor toxicity in healthy cells represents a critical challengeto clinical applications in cancer treatment. Researchers are currentlyexploring strategies to enhance targeted degradation activity in acell-selective manner to minimize undesirable side effects. In thisPerspective, we highlight innovative approaches for prodrug-basedPROTACs (pro-PROTACs) that facilitate tumor-targeted release. Thedevelopment of such approaches may further expand the range of potentialapplications of PROTAC technology within drug development. |
| WOS关键词 | INDUCED PROTEIN-DEGRADATION ; ANTIBODY-MEDIATED DELIVERY ; CHIMERAS PROTACS ; STRATEGIES ; DISCOVERY |
| 资助项目 | National Natural Science Foundation of China[22277131] ; Shanghai Pujiang Program[21PJ1415900] ; CAS Pioneer Hundred Talents Program |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001009453900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306233]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Xuan |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Dev Ctr, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Chuanjie,Yang, Yiwen,Wang, Zhe,et al. Recent Advances in Pro-PROTAC Development to Address On-Target Off-Tumor Toxicity[J]. JOURNAL OF MEDICINAL CHEMISTRY,2023:13. |
| APA | Chen, Chuanjie,Yang, Yiwen,Wang, Zhe,Li, Huiwen,Dong, Chanjuan,&Zhang, Xuan.(2023).Recent Advances in Pro-PROTAC Development to Address On-Target Off-Tumor Toxicity.JOURNAL OF MEDICINAL CHEMISTRY,13. |
| MLA | Chen, Chuanjie,et al."Recent Advances in Pro-PROTAC Development to Address On-Target Off-Tumor Toxicity".JOURNAL OF MEDICINAL CHEMISTRY (2023):13. |
入库方式： OAI收割
来源：上海药物研究所
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