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Self-Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer

文献类型：期刊论文

作者Wang, Weiqi1,2; Zhu, Qiwen2; Jin, Yilan1,2; Gao, Jing2; Li, Jianan1; Zheng, Xiaohua1; Gao, Weidong3; Saeed, Madiha2,4; Sheng, Weizhong3; Yu, Haijun2
刊名ADVANCED HEALTHCARE MATERIALS
出版日期2023-06-13
页码13
ISSN号2192-2640
关键词antigen presentation immunogenic cell death nanoadjuvant photodynamic therapy vaccination immunotherapy
DOI10.1002/adhm.202300524
通讯作者Saeed, Madiha(madihasaeed@cuilahore.edu.pk) ; Sheng, Weizhong(Sheng.weizhong@zs-hospital.sh.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要Vaccination immunotherapy has revolutionized cancer treatment modalities. Although the immunomodulatory adjuvant generally employs for potentiating vaccine response, systemic administration may drive immune-related side effects, even immune tolerance. Therefore, tunable immunoadjuvants are highly desirable to simultaneously stimulate the immune response and mitigate systemic toxicity. Self-immolated nanoadjuvants are herein reported to potentiate vaccination immunotherapy of cancer. The nanoadjuvants are engineered by co-assembling an intracellular acidity-ionizable polymeric agonist of toll-like receptor 7/8 resiquimod (R848) and polymeric photosensitizer pyropheophorbide a (PPa). The resultant nanoadjuvants specifically accumulated at the tumor site via passive targeting and are dissociated in the acidic endosome versicles to activate PPa via protonation of the polymer backbone. Upon 671 nm laser irradiation, PPa performed photodynamic therapy to induce immunogenic cell death of tumor cells and subsequently released R848 in a customized manner, which synergistically activated dendritic cells (DCs), promoted antigen cross-presentation, and eventually recruited cytotoxic T lymphocytes for tumor regression. Furthermore, the synergistic in situ vaccination immunotherapy with immune checkpoint blockade induce sustained immunological memory to suppress tumor recurrence in the rechallenged colorectal tumor model.
WOS关键词IMMUNOGENIC CELL-DEATH ; PHOTODYNAMIC THERAPY ; MECHANISMS ; NANOPARTICLES ; MOLECULES ; ADJUVANT ; ROS
资助项目National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[U22A20328] ; Lingang Laboratory[LG-QS-202206-04] ; International Cooperation Project of Science and Technology Commission of Shanghai Municipality[20430711800] ; Large Instruments Open Foundation of Nantong University[KFJN2264] ; Large Instruments Open Foundation of Nantong University[KFJN2271]
WOS研究方向Engineering ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:001008371500001
源URL[http://119.78.100.183/handle/2S10ELR8/306236]  
专题中国科学院上海药物研究所
通讯作者Saeed, Madiha; Sheng, Weizhong; Yu, Haijun
作者单位1.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China
4.COMSATS Univ Islamabad, Interdisciplinary Res Ctr Biomed Mat, Lahore Campus, Lahore 54000, Pakistan
推荐引用方式
GB/T 7714		 Wang, Weiqi,Zhu, Qiwen,Jin, Yilan,et al. Self-Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2023:13.
APA Wang, Weiqi.,Zhu, Qiwen.,Jin, Yilan.,Gao, Jing.,Li, Jianan.,...&Yu, Haijun.(2023).Self-Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer.ADVANCED HEALTHCARE MATERIALS,13.
MLA Wang, Weiqi,et al."Self-Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer".ADVANCED HEALTHCARE MATERIALS (2023):13.

入库方式： OAI收割

来源：上海药物研究所

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