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Bisabolane-Type Sesquiterpenoids with a Tetrahydrofuran or Tetrahydropyran Ring from Vernonia solanifolia

文献类型：期刊论文

作者Li, Zeng1,2,3; Yang, Yue2,3; Chen, Cheng4; Lin, Ligen4; Tang, Chunping2,3; Ye, Yang1,2,3,5
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2023-06-07
页码14
ISSN号0163-3864
DOI10.1021/acs.jnatprod.3c00253
通讯作者Yang, Yue(yangyue1@simm.ac.cn) ; Tang, Chunping(tangcp@simm.ac.cn) ; Ye, Yang(yye@simm.ac.cn)
英文摘要Phytochemical investigation of the aerial parts of Vernoniasolanifolia resulted in the isolation of 23 new highly oxidizedbisabolane-type sesquiterpenoids (1-23). Structures were determined by interpretation of spectroscopicdata, single-crystal X-ray diffraction analysis, and time-dependentdensity functional theory electronic circular dichroism calculations.Most compounds possess a rare tetrahydrofuran (1-17) or tetrahydropyran ring (18-21). Compounds 1/2 and 11/12 are pairs of epimers isomerized at C-10, while compounds 9/10 and 15/16 areisomerized at C-11 and C-2, respectively. The anti-inflammatory effectin lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was evaluatedfor pure compounds. Compound 9 inhibited LPS-stimulatedNO production at the concentration of 80 mu M.It showed an anti-inflammatory effect by suppressing the activationof the NF-kappa B signaling pathway.
WOS关键词LACTONES ; SEEDS ; ANTHELMINTICA ; DERIVATIVES
资助项目National Natural Science Foundation of China[21920102003] ; National Natural Science Foundation of China[81903485] ; Science and Technology Commission of Shanghai Municipality[20430780300] ; Research Fund of University of Macau[MYRG2020-00091-ICMS] ; Research Fund of University of Macau[MYRG2022-00177-ICMS]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001007730400001
源URL[http://119.78.100.183/handle/2S10ELR8/306239]  
专题新药研究国家重点实验室
通讯作者Yang, Yue; Tang, Chunping; Ye, Yang
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
4.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macau, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zeng,Yang, Yue,Chen, Cheng,et al. Bisabolane-Type Sesquiterpenoids with a Tetrahydrofuran or Tetrahydropyran Ring from Vernonia solanifolia[J]. JOURNAL OF NATURAL PRODUCTS,2023:14.
APA Li, Zeng,Yang, Yue,Chen, Cheng,Lin, Ligen,Tang, Chunping,&Ye, Yang.(2023).Bisabolane-Type Sesquiterpenoids with a Tetrahydrofuran or Tetrahydropyran Ring from Vernonia solanifolia.JOURNAL OF NATURAL PRODUCTS,14.
MLA Li, Zeng,et al."Bisabolane-Type Sesquiterpenoids with a Tetrahydrofuran or Tetrahydropyran Ring from Vernonia solanifolia".JOURNAL OF NATURAL PRODUCTS (2023):14.

入库方式： OAI收割

来源：上海药物研究所

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