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New Meroterpenoids and Anti-Osteoclastogenic Polyketides from the Mangrove-Derived fungus Arthrinium sp. SCSIO 41306

文献类型：期刊论文

作者Hu, Yiwei3,6; Qi, Xin3; Chen, Weihao3; Liao, Shengrong3; Yang, Dehua1,5; Wang, Mingwei1,5; Liu, Yonghong2,3,6; Tan, Yanhui4; Wang, Junfeng2,3,6
刊名CHEMISTRY & BIODIVERSITY
出版日期2023-06-02
页码6
ISSN号1612-1872
关键词Arthrinium meroterpenoids NF-kappa B osteoclastogenesis PI3K
DOI10.1002/cbdv.202300551
通讯作者Tan, Yanhui(tyh533@126.com) ; Wang, Junfeng(wangjunfeng@scsio.ac.cn)
英文摘要Two new meroterpenoids, arthrinones A and B (1 and 2), along with six known compounds (3-8), were obtained from the fungus Arthrinium sp. SCSIO 41306. Comprehensive methods such as chiral-phase HPLC analysis and ECD calculations were applied to determine the absolute configurations. Griseofulvin (5), kojic acid (6), and 1H-indole-3-carboxaldehyde (8) showed inhibition of NF-kappa B in RAW 264.7 macrophages induced by lipopolysaccharide (LPS) with IC50 values of 22.21, 13.87 and 19.31 mu M, respectively. In addition, griseofulvin (5) inhibited receptor activator of NF-kappa B ligand (RANKL)-induced osteoclast differentiation in a dose-dependent manner without visible evidence of cytotoxicity in bone marrow macrophages (BMMs). This is the first report on the activity of griseofulvin (5) to inhibit osteoclast formation (IC50 10.09. 0.21 mu M).
WOS关键词INHIBITORS
资助项目Guangdong Basic and Applied Basic Research Foundation[2021A1515011523] ; Guangdong Basic and Applied Basic Research Foundation[2021B1515120046] ; Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City[2021JJLH0097] ; Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City[2021CXLH0013] ; Hainan Provincial Natural Science Foundation of China[823CXTD393] ; Guangxi Young and Middle-aged University Teachers' Scientific Research Ability Enhancement Project[2021KY0062] ; National Natural Science Foundation of China[82104496] ; National Natural Science Foundation of China[82073762] ; National Natural Science Foundation of China[41776169]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000999481100001
源URL[http://119.78.100.183/handle/2S10ELR8/306242]  
专题中国科学院上海药物研究所
通讯作者Tan, Yanhui; Wang, Junfeng
作者单位1.Res Ctr Deepsea Bioresources, Sanya 572025, Peoples R China
2.Sanya Inst Ocean Ecoenvironm Engn, Sanya 572000, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, Innovat Acad South China Sea Ecol & Environm Engn, CAS Key Lab Trop Marine Bioresources & Ecol,Guangd, Guangzhou 510301, Peoples R China
4.Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541001, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drugs Screening, Shanghai 201203, Peoples R China
6.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Yiwei,Qi, Xin,Chen, Weihao,et al. New Meroterpenoids and Anti-Osteoclastogenic Polyketides from the Mangrove-Derived fungus Arthrinium sp. SCSIO 41306[J]. CHEMISTRY & BIODIVERSITY,2023:6.
APA Hu, Yiwei.,Qi, Xin.,Chen, Weihao.,Liao, Shengrong.,Yang, Dehua.,...&Wang, Junfeng.(2023).New Meroterpenoids and Anti-Osteoclastogenic Polyketides from the Mangrove-Derived fungus Arthrinium sp. SCSIO 41306.CHEMISTRY & BIODIVERSITY,6.
MLA Hu, Yiwei,et al."New Meroterpenoids and Anti-Osteoclastogenic Polyketides from the Mangrove-Derived fungus Arthrinium sp. SCSIO 41306".CHEMISTRY & BIODIVERSITY (2023):6.

入库方式： OAI收割

来源：上海药物研究所

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