Molecular and Cellular Mechanisms of Neuropathic Pain in Aging
文献类型：期刊论文
| 作者 | Huang, Han2; Wu, Jianwei2; Chang, Yi3; Wang, Hongwei2; Tian, Ye2; Chen, Zhenhao2; Feng, Jing1,4; Wang, Hongli2 |
| 刊名 | ACS CHEMICAL NEUROSCIENCE
 |
| 出版日期 | 2023-04-27 |
| 卷号 | 14期号:10页码:1701-1716 |
| 关键词 | neuropathic pain aging intracellular calciumconcentration oxidative stress brain function descending inhibition innate immune cell population central nervous system comorbidity |
| ISSN号 | 1948-7193 |
| DOI | 10.1021/acschemneuro.3c00010 |
| 通讯作者 | Chen, Zhenhao(chenzhenhao17@126.com) ; Feng, Jing(fengjing@simm.ac.cn) ; Wang, Hongli(wanghongli0212@163.com) |
| 英文摘要 | Neuropathic pain is a chronic condition that tends toworsen overtime, leading to a significant decline in patients' qualityof life. The elderly population is disproportionately affected bythis burden, as evidenced by the high prevalence of this conditionin such a demographic. While previous studies have demonstrated theinvolvement of various signaling pathways critical to neuropathicpain, the relationship between aging and the onset or persistenceof this condition has been overlooked. Greater focus was placed onthe efficacy and tolerability of medications, as well as new protocolsfor assessing pain in patients with cognitive impairment, with lessregard for reasons underlying the increased susceptibility of elderlyindividuals to pain. This Review thus aims to summarize the contributionsof aging to neuropathic pain, covering weakened repair function, increasedintracellular calcium signaling, enhanced oxidative stress, dysfunctionalbrain function, impaired descending inhibition, alterations in theinnate immune cell population, and the effects of comorbidity causedby aging. A better understanding of these aspects could drive newtreatment options thereby yielding better outcomes for elderly patientsin pain. |
| WOS关键词 | DORSAL-ROOT GANGLION ; MU-OPIOID RECEPTOR ; CHRONIC BACK-PAIN ; POSTHERPETIC NEURALGIA ; DIABETIC-NEUROPATHY ; CALCIUM-CHANNELS ; SENSORY NEURONS ; HERPES-ZOSTER ; UP-REGULATION ; SPINAL-CORD |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001006815000001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306245]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Zhenhao; Feng, Jing; Wang, Hongli |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Neurol & Psychiat Res & Drug Discovery, Shanghai 201203, Peoples R China 2.Fudan Univ, Huashan Hosp, Dept Orthoped, Shanghai 200040, Peoples R China 3.Tongji Univ, Yangpu Hosp, Sch Med, Shanghai 200090, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Han,Wu, Jianwei,Chang, Yi,et al. Molecular and Cellular Mechanisms of Neuropathic Pain in Aging[J]. ACS CHEMICAL NEUROSCIENCE,2023,14(10):1701-1716. |
| APA | Huang, Han.,Wu, Jianwei.,Chang, Yi.,Wang, Hongwei.,Tian, Ye.,...&Wang, Hongli.(2023).Molecular and Cellular Mechanisms of Neuropathic Pain in Aging.ACS CHEMICAL NEUROSCIENCE,14(10),1701-1716. |
| MLA | Huang, Han,et al."Molecular and Cellular Mechanisms of Neuropathic Pain in Aging".ACS CHEMICAL NEUROSCIENCE 14.10(2023):1701-1716. |
入库方式： OAI收割
来源：上海药物研究所
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