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Suadimins D-J, Monoterpenoid Indole-Quinoline and Bisindole Alkaloids from Melodinus suaveolens

文献类型：期刊论文

作者Gao, Xin-Hua1; Wu, Pei-Qian1; Fan, Yao-Yue1,2; Zhou, Bin1,2; Yue, Jian-Min1,2,3
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2023-06-12
页码2296-2304
ISSN号1001-604X
关键词Melodinus suaveolens Alkaloids Dimerization Structure elucidation ECD calculations Cytotoxic activity
DOI10.1002/cjoc.202300209
通讯作者Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Compounds 1-12, including seven complex monoterpenoid indole-quinoline and bisindole alkaloids, suadimins D-J (1-7) with previously unreported carbon-carbon linkages, were isolated and identified from the twigs and leaves of Melodinus suaveolens. Their structures were elucidated by a combination of diverse methods, especially the extensive spectroscopic data analysis and electric circular dichroism (ECD) calculations. The cytotoxicity of these compounds against three cancer cell lines was evaluated, some of which showed moderate activities with IC50 values ranging from 2.4 to 8.0 mu M.
WOS关键词ELECTRONIC CIRCULAR-DICHROISM
资助项目National Natural Science Foundation of China[22007095] ; National Natural Science Foundation of China[82293685] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Biological Resources Program, CAS[KFJ-BRP-008-001]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:001007178000001
源URL[http://119.78.100.183/handle/2S10ELR8/306251]  
专题新药研究国家重点实验室
通讯作者Zhou, Bin; Yue, Jian-Min
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
3.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Xin-Hua,Wu, Pei-Qian,Fan, Yao-Yue,et al. Suadimins D-J, Monoterpenoid Indole-Quinoline and Bisindole Alkaloids from Melodinus suaveolens[J]. CHINESE JOURNAL OF CHEMISTRY,2023:2296-2304.
APA Gao, Xin-Hua,Wu, Pei-Qian,Fan, Yao-Yue,Zhou, Bin,&Yue, Jian-Min.(2023).Suadimins D-J, Monoterpenoid Indole-Quinoline and Bisindole Alkaloids from Melodinus suaveolens.CHINESE JOURNAL OF CHEMISTRY,2296-2304.
MLA Gao, Xin-Hua,et al."Suadimins D-J, Monoterpenoid Indole-Quinoline and Bisindole Alkaloids from Melodinus suaveolens".CHINESE JOURNAL OF CHEMISTRY (2023):2296-2304.

入库方式： OAI收割

来源：上海药物研究所

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