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Unprecedented spirodioxynaphthalenes from the endophytic fungus Phyllosticta ligustricola HDF-L-2 derived from the endangered conifer Pseudotsuga gaussenii

文献类型：期刊论文

作者Chen, Hao-Wei2; Jiang, Chun-Xiao2,3; Ma, Guang-Lei2; Wu, Xi-Ying2; Jiang, Wei2; Li, Jiyang2; Zang, Yi4; Li, Jia4; Xiong, Juan2; Hu, Jin-Feng1,2,3
刊名PHYTOCHEMISTRY
出版日期2023-07-01
卷号211页码:10
ISSN号0031-9422
关键词Phyllosticta ligustricola Phyllostictaceae Pseudotsuga gaussenii Pinaceae Phyligustricins A-D Spirodioxynaphthalenes Antimicrobial effects Cytotoxicity ACL/ACC1 inhibitory effects
DOI10.1016/j.phytochem.2023.113687
通讯作者Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要Four undescribed palmarumycin-type spirodioxynaphthalenes (phyligustricins A-D) and a known biogenetic precursor (palmarumycin BG1) were isolated from a solid fermentation of Phyllosticta ligustricola HDF-L-2, an endophyte associated with the endangered Chinese conifer Pseudotsuga gaussenii. The structures were elucidated by spectroscopic methods, single-crystal X-ray diffraction analyses, and electronic circular dichroism calculations. Both phyligustricins A and B have an unprecedented spirodioxynaphthalene-derived skeleton containing an extra 4H-furo [3,2-c]pyran-4-one moiety, while phyligustricins C and D are p-hydroxy-phenethyl substituted spirodioxynaphthalenes. The plausible biosynthetic relationships of the isolates were briefly proposed. Phyligustricins C and D and palmarumycin BG1 showed considerable antibacterial activity against Staphylococcus aureus, each with an MIC value of 16 mu g/mL. Palmarumycin BG1 displayed significant inhibitory effects against ACL and ACC1, with IC50 values of 1.60 and 8.00 mu M, respectively.
WOS关键词III POLYKETIDE SYNTHASE ; A-F ; METABOLITES ; SESQUITERPENOIDS ; DERIVATIVES ; INHIBITORS ; PYRONE
资助项目National Natural Science Foundation of China[21937002] ; National Natural Science Foundation of China[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000992860600001
源URL[http://119.78.100.183/handle/2S10ELR8/306254]  
专题新药研究国家重点实验室
通讯作者Xiong, Juan; Hu, Jin-Feng
作者单位1.Fudan Univ, Shanghai 201203, Peoples R China
2.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China
3.Taizhou Univ, Sch Pharmaceut Sci, Zhejiang Prov Key Lab oratory Plant Evolutionary E, Taizhou 318000, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Hao-Wei,Jiang, Chun-Xiao,Ma, Guang-Lei,et al. Unprecedented spirodioxynaphthalenes from the endophytic fungus Phyllosticta ligustricola HDF-L-2 derived from the endangered conifer Pseudotsuga gaussenii[J]. PHYTOCHEMISTRY,2023,211:10.
APA Chen, Hao-Wei.,Jiang, Chun-Xiao.,Ma, Guang-Lei.,Wu, Xi-Ying.,Jiang, Wei.,...&Hu, Jin-Feng.(2023).Unprecedented spirodioxynaphthalenes from the endophytic fungus Phyllosticta ligustricola HDF-L-2 derived from the endangered conifer Pseudotsuga gaussenii.PHYTOCHEMISTRY,211,10.
MLA Chen, Hao-Wei,et al."Unprecedented spirodioxynaphthalenes from the endophytic fungus Phyllosticta ligustricola HDF-L-2 derived from the endangered conifer Pseudotsuga gaussenii".PHYTOCHEMISTRY 211(2023):10.

入库方式： OAI收割

来源：上海药物研究所

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